| Gene Symbol | WTAP |
| Aliases | Wilms' Tumor 1-Associated Protein |
| Function | WTAP (Wilms' Tumor 1-Associated Protein) is a 399-amino acid nuclear protein that serves as a regulatory subunit of the N6-methyladenosine (m6A) methyltransferase complex. |
| Subcellular Localization | </strong> Nucleus (nuclear speckles)</div> <div class="infobox-row"><strong>Pr |
| Molecular Weight | 44.2 kDa |
| Amino Acids | 399 aa |
| Pathways | Wnt, Tgf-Β, Ferroptosis |
| GeneCards | WTAP |
| Human Protein Atlas | WTAP |
| m6A Complex Assembly | WTAP is essential for the nuclear localization and stability of the m6A methyltransferase complex |
| Alternative Splicing | WTAP influences alternative splicing decisions by recruiting splicing factors to methylated transcripts |
| Synaptic Function | The m6A pathway regulates synaptic protein expression, and WTAP dysfunction affects synaptic transmission and plasticity |
| Neuronal Development | Essential for proper neuronal differentiation and brain development; knockout causes embryonic lethality in mice |
| Stress Response | WTAP expression is regulated in response to cellular stress, affecting m6A modification of stress response transcripts |
| Modulator Development | Small molecules enhancing WTAP-protein interactions could stabilize the methyltransferase complex |
| Associated Diseases | Als, Cancer |
| Interactions | ACSL5, BAMBI, CSF2, FERROPTOSIS, HDAC5, METTL3 |
| KG Connections | 79 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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