protein

METTL14

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about METTL14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

4Outgoing

6Incoming

0Experiments

0Debates

Summary

Page for METTL14 Protein (m6A Methyltransferase Subunit)

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🔬 Protein Info

Gene Symbol	METTL14
Aliases	m6A Methyltransferase Subunit
Function	METTL14 (Methyltransferase Like 14) is a 456-amino acid protein that forms the substrate recognition component of the m6A methyltransferase complex.
Subcellular Localization	</strong> Nucleus, cytosol</div> <div class="infobox-row"><strong>Protein Fami
Molecular Weight	59.6 kDa
Amino Acids	456 aa
GeneCards	METTL14
Human Protein Atlas	METTL14
Interactions	NESTIN
KG Connections	10 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

METTL14 Protein (m6A Methyltransferase Subunit)

protein · 699 words

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Pathway Diagram

flowchart TD
    METTL14(["METTL14"])
    m6A_Modification("m6A Modification")
    m6A_RNA_Methylation("m6A RNA Methylation")
    ICE1["ICE1"]
    NESTIN(["NESTIN"])
    MITOCHONDRIA["MITOCHONDRIA"]

    METTL14 -->|"catalyzes"| m6A_Modification
    METTL14 -->|"catalyzes"| m6A_RNA_Methylation
    METTL14 -->|"interacts with"| ICE1
    NESTIN -->|"activates"| METTL14
    MITOCHONDRIA -->|"expressed in"| METTL14

    style METTL14 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (4)

Target	Relation	Type	Str
N6-Methyladenosine	regulates	compound	0.95
m6A modification	mediates	process	0.95
WTAP	expressed_in	gene	0.60
YTHDF2	associated_with	gene	0.60

Incoming (6)

Source	Relation	Type	Str
E6	degrades	protein	0.95
HPV E6	degrades	protein	0.95
E6AP	mediates	protein	0.90
HNRNPA2B1	associated_with	gene	0.60
NESTIN	activates	gene	0.50
MITOCHONDRIA	expressed_in	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning METTL14 in their description or question text

No additional research found