gene

VGLUT2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VGLUT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections

0Hypotheses

0Analyses

35Outgoing

20Incoming

0Experiments

0Debates

Summary

Vesicular Glutamate Transporter 2 - essential for glutamatergic neurotransmission in subcortical pathways, implicated in Parkinson's disease and neurological disorders

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🧬 Gene Info

Gene Symbol	VGLUT2
Aliases	Vesicular Glutamate Transporter 2
Chromosome	19q13.43
Protein Type	Gene
Function	Its function encompasses several critical processes
Primary Expression	hypothalamic nuclei controlling autonomic and endocrine functions - Cortex: Limited to deep layers (V-VI) and specific interneuron populations -
Molecular Weight	65 kDa
Amino Acids	582 aa
Pathways	Epigenetic, Synaptic Plasticity, Synaptic Vesicle
GeneCards	VGLUT2
Human Protein Atlas	VGLUT2
Thalamus	Highest expression across all thalamic relay nuclei, particularly the ventral posterolateral and ventral posteromedial nuclei[@schoch2016]
Brainstem	Abundant in the red nucleus, substantia nigra pars reticulata, superior colliculus, and pontine nuclei[@tondereau2008]
Spinal Cord	Prominent in dorsal horn neurons, especially laminae I-II involved in pain transmission[@shabel2014]
Hypothalamus	Expressed in hypothalamic nuclei controlling autonomic and endocrine functions
Associated Diseases	epilepsy, Ischemia, neurodegeneration
Interactions	6-OHDA, AND, ANXIETY, CSF1R, EPILEPSY, ERK1
KG Connections	55 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

VGLUT2 Gene

gene · 2948 words

→

VGLUT2 Protein

protein · 595 words

→

Pathway Diagram

graph TD
    VGLUT2["VGLUT2"]
    Ms["Ms"]
    Parkinson["Parkinson"]
    Als["Als"]
    Aging["Aging"]
    Ischemia["Ischemia"]
    Epilepsy["Epilepsy"]
    Neurodegeneration["Neurodegeneration"]
    AND["AND"]
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    Epigenetic["Epigenetic"]
    Synaptic_Plasticity["Synaptic Plasticity"]
    Neuron["Neuron"]
    ERK1["ERK1"]
    SLC17A6["SLC17A6"]
    N6_OHDA["6-OHDA"]
    PARKINSON["PARKINSON"]
    VGLUT1["VGLUT1"]
    EPILEPSY["EPILEPSY"]
    SLC17A7["SLC17A7"]
    VGLUT2 -.->|"inhibits"| Ms
    VGLUT2 -.->|"inhibits"| Parkinson
    VGLUT2 -.->|"inhibits"| Als
    VGLUT2 -.->|"inhibits"| Aging
    VGLUT2 -.-|"associated"| Ischemia
    VGLUT2 -.->|"inhibits"| Epilepsy
    VGLUT2 -.->|"inhibits"| Neurodegeneration
    VGLUT2 -.->|"inhibits"| AND
    VGLUT2 -.->|"inhibits"| PARKINSON_S_DISEASE
    VGLUT2 -->|"activates"| Epigenetic
    VGLUT2 -->|"activates"| Synaptic_Plasticity
    VGLUT2 -->|"expressed in"| Neuron
    VGLUT2 -.->|"inhibits"| Neuron
    ERK1 -.->|"inhibits"| VGLUT2
    SLC17A6 -.-|"associated"| VGLUT2
    N6_OHDA -.->|"inhibits"| VGLUT2
    PARKINSON -.->|"inhibits"| VGLUT2
    VGLUT1 -.-|"associated"| VGLUT2
    EPILEPSY -.->|"inhibits"| VGLUT2
    SLC17A7 -->|"activates"| VGLUT2
    style VGLUT2 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (35)

Target	Relation	Type	Str
Epilepsy	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Als	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Ischemia	associated_with	disease	0.65
Epigenetic	activates	pathway	0.60
Synaptic Plasticity	activates	pathway	0.60
Neuron	expressed_in	cell_type	0.60
Neuron	inhibits	cell_type	0.60
SLC17A7	activates	gene	0.60
AND	inhibits	gene	0.60
KDM6B	expressed_in	gene	0.60
VGLUT1	expressed_in	gene	0.60
SLC17A6	activates	gene	0.60
TAU	activates	gene	0.60
Synaptic Vesicle	activates	pathway	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
Il-1	regulates	protein	0.60
neurodegeneration	associated_with	disease	0.60
Monocyte	activates	cell_type	0.60
epilepsy	associated_with	disease	0.60
EPILEPSY	inhibits	gene	0.60
ANXIETY	activates	gene	0.60
MICROGLIA	regulates	gene	0.60
Neuron	regulates	cell_type	0.60
VGLUT1	associated_with	gene	0.60
NEURON	expressed_in	gene	0.60
neurons	expressed_in	cell_type	0.60
cortex	expressed_in	brain_region	0.60
Dentate Gyrus	expressed_in	brain_region	0.55
Hippocampus	expressed_in	brain_region	0.55
ISCHEMIA	associated_with	disease	0.50
NEURONS	expressed_in	concept	0.50

Incoming (20)

Source	Relation	Type	Str
NEURODEGENERATION	inhibits	gene	0.60
ERK1	inhibits	gene	0.60
SLC17A6	associated_with	gene	0.60
EPILEPSY	inhibits	gene	0.60
NEURON	expressed_in	gene	0.60
CSF1R	activates	gene	0.60
6-OHDA	inhibits	gene	0.60
PARKINSON	inhibits	gene	0.60
ERK1/2	inhibits	gene	0.60
IL-1	regulates	gene	0.60
RNA	regulates	gene	0.60
VGLUT1	associated_with	gene	0.60
SLC17A7	activates	gene	0.60
KDM6B	expressed_in	gene	0.60
SLC17A6	activates	gene	0.60
VGLUT1	expressed_in	gene	0.60
TAU	activates	gene	0.60
MMP9	expressed_in	gene	0.60
VGLUT1	regulates	gene	0.60
VGLUT1	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VGLUT2 in their description or question text

No additional research found