| Gene Symbol | VGLUT2 |
| Aliases | Vesicular Glutamate Transporter 2 |
| Chromosome | 19q13.43 |
| Protein Type | Gene |
| Function | Its function encompasses several critical processes |
| Primary Expression | hypothalamic nuclei controlling autonomic and endocrine functions - Cortex: Limited to deep layers (V-VI) and specific interneuron populations - |
| Subcellular Localization | Synaptic vesicles of glutamatergic neurons |
| Molecular Weight | 65 kDa |
| Amino Acids | 582 aa |
| Pathways | Epigenetic, Synaptic Plasticity, Synaptic Vesicle |
| GeneCards | VGLUT2 |
| Human Protein Atlas | VGLUT2 |
| 12 transmembrane domains | Characteristic of the major facilitator superfamily |
| Vesicular lumen orientation | Transports glutamate into the vesicle lumen |
| Proton gradient coupling | Uses V-ATPase-generated H+ gradient for transport |
| Associated Diseases | epilepsy, Ischemia, neurodegeneration |
| Interactions | 6-OHDA, AND, ANXIETY, CSF1R, EPILEPSY, ERK1 |
| KG Connections | 56 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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