gene 1,812 words KG: VGLUT1
Contents

VGLUT1 Gene

🧬 Gene Info
Gene SymbolVGLUT1
AliasesVesicular Glutamate Transporter 1
Chromosome19q13.33
Primary Expressionglutamatergic (excitatory) neurons
Molecular Weight62 kDa
Amino Acids560 aa
Exons12
PathwaysAmyloid, Apoptosis
Ensembl IDENSG00000177656
GeneCardsVGLUT1
Human Protein AtlasVGLUT1
Cerebral cortexHighest in layers II-III and V (pyramidal neurons)
HippocampusCA1-CA3 pyramidal cells, dentate gyrus granule cells
Olfactory bulbMitral and tufted cells
ThalamusSpecific relay nuclei
Associated Diseasesepilepsy, excitatory neuron loss, ISCHEMIA, neurodegeneration
InteractionsAkt, ALZHEIMER, ALZHEIMER'S DISEASE, APOE, APOE3, APOE4
KG Connections198 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (6)

Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
APOE-Dependent Autophagy Restoration
Score: 0.88
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69

Related Analyses (5)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

s:** - Test whether HCN1 knockout specifically in EC layer I
falsification · proposed · Score: 0.40

See Also (9)

blarcamesine-axon
clinical_trial · KG edge: regulates
Apoptosis in Neurodegeneration
entity · KG edge: regulates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: biomarker_for
BACE1 (Redirect)
redirect · KG edge: regulates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: activates

Knowledge Graph (12 edges)

VGLUT1 associated_with LAMP1
VGLUT1 encoded_by SLC17A7
VGLUT1 localized_to SYNAPTIC_VESICLE
VGLUT1 pharmacological_target TRORILUZOLE
VGLUT1 activates TAU
VGLUT1 activates APOE
VGLUT1 activates APOE4
VGLUT1 activates VEGF
VGLUT1 activates GFAP
VGLUT1 associated_with VGLUT2

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