| Gene Symbol | TNFRSF1B |
| Aliases | TNFR2 |
| Protein Type | Receptor |
| Function | encodes a type I membrane receptor for tumor necrosis factor (TNF). |
| Subcellular Localization | ** | Plasma membrane (type I transmembrane) | |
| Molecular Weight | 75 kDa |
| Amino Acids | 461 aa |
| Exons | 10 |
| Pathways | NF-κB, NF-κB pathway, PI3K, MAPK pathway, MAPK Pathway |
| Ensembl ID | ENSG00000028137 |
| GeneCards | TNFRSF1B |
| Human Protein Atlas | TNFRSF1B |
| Extracellular domain | Four cysteine-rich domains (CRD1-4) that form the TNF-binding interface |
| CRD1 | Pre-ligand assembly domain (PLAD) mediating receptor trimerization |
| CRD2-3 | Primary TNF contact surfaces |
| Associated Diseases | Cancer, Chronic Pain, Leukemia, Lung Cancer, Pain |
| Interactions | ADRA2B, AND, ASTROCYTE, CHRM4, CHRNE, CRH |
| KG Connections | 60 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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