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protein 1,173 words KG: TMEM106B
Contents

TMEM106B Protein (Transmembrane Protein 106B)

🔬 Protein Info
Gene SymbolTMEM106B
AliasesTransmembrane Protein 106B
Chromosome7p21.3
Protein FamilyType II lysosomal transmembrane protein family
Functionis a 323-amino acid type II lysosomal transmembrane protein encoded by the TMEM106B gene on chromosome 7p21.
Primary ExpressionLate endosomes and lysosomes
Molecular Weight30.3 kDa
Amino Acids274 aa
Exons9
PathwaysAutophagy, endosome-lysosome function
UniProt IDQ9NUM4
GeneCardsTMEM106B
Human Protein AtlasTMEM106B
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease
InteractionsActin, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, AND, APOE
KG Connections383 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (14)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedProtein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (1)

TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism an
validation · proposed · Score: 0.40

See Also (8)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activatesABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_withABI3 Gene
gene · KG edge: associated_withACE Gene
gene · KG edge: associated_withadam17
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TMEM106B regulates endosome-lysosome function
TREM2 associated_with TMEM106B
TMEM106B associated_with SIGLEC9
TMEM106B associated_with SIRPA
TMEM106B associated_with GRN
MAPT associated_with TMEM106B
TMEM106B associated_with C9ORF72
TMEM106B interacts_with NFL
SIGLEC9 associated_with TMEM106B
TMEM106B associated_with CTSH

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