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protein 1,600 words KG: TMEM106B
Contents

TMEM106B

🔬 Protein Info
Gene SymbolTMEM106B
AliasesTransmembrane Protein 106B
Chromosome7p21.3
Protein FamilyType II lysosomal transmembrane protein family
Functionis a 323-amino acid type II lysosomal transmembrane protein encoded by the TMEM106B gene on chromosome 7p21.
Primary ExpressionLate endosomes and lysosomes
Molecular Weight30.3 kDa
Amino Acids274 aa
Exons9
PathwaysAutophagy, endosome-lysosome function
UniProt IDQ9NUM4
GeneCardsTMEM106B
Human Protein AtlasTMEM106B
Molecular weightApproximately 31 kDa
TopologyType II transmembrane protein (N-out, C-in)
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease
InteractionsActin, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, AND, APOE
KG Connections383 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (20)

Lysosomal Membrane Repair Enhancement
Score: 0.54APOE-Dependent Autophagy Restoration
Score: 0.85Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE-TREM2 Interaction Modulation
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Cross-Seeding Prevention Strategy
Score: 0.69TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62TREM2-mediated microglial tau clearance enhancement
Score: 0.59TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58TREM2-Dependent Microglial Senescence Transition
Score: 0.54

Related Analyses (6)

RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedProtein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism an
validation · proposed · Score: 0.40

See Also (8)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activatesABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_withABI3 Gene
gene · KG edge: associated_withACE Gene
gene · KG edge: associated_withadam17
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TMEM106B regulates endosome-lysosome function
TREM2 associated_with TMEM106B
TMEM106B associated_with SIGLEC9
TMEM106B associated_with SIRPA
TMEM106B associated_with GRN
MAPT associated_with TMEM106B
TMEM106B associated_with C9ORF72
TMEM106B interacts_with NFL
SIGLEC9 associated_with TMEM106B
TMEM106B associated_with CTSH

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