concept

SULFORAPHANE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SULFORAPHANE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

77Connections

1Hypotheses

0Analyses

50Outgoing

17Incoming

0Experiments

0Debates

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💡 Concept Info

Name	SULFORAPHANE
Key Genes/Proteins	AKT, AQP4, BDNF, CREB, ERK, HDAC2
Related Diseases	ALZHEIMER, ALZHEIMER'S DISEASE, ATHEROSCLEROSIS, AUTOPHAGY, CHOLESTEROL

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Sulforaphane and Nrf2 Activation for Neuroprotection

therapeutic · 4477 words

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Pathway Diagram

graph TD
    SULFORAPHANE["SULFORAPHANE"]
    SULFORAPHANE -->|"activates"| TFEB["TFEB"]
    SULFORAPHANE -->|"activates"| lipophagy["lipophagy"]
    SULFORAPHANE -->|"activates"| AMPK["AMPK"]
    SULFORAPHANE -->|"mediates"| TFEB_Nuclear_Translocation["TFEB Nuclear Translocation"]
    SULFORAPHANE -->|"treats"| Oxidative_Stress["Oxidative Stress"]
    SULFORAPHANE -->|"contributes to"| LC3["LC3"]
    SULFORAPHANE -->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    SULFORAPHANE -->|"suppresses"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]

Outgoing (60)

Target	Relation	Type	Str
h-5050522d	targeted_by	hypothesis	1.00
TFEB	activates	protein	0.95
lipophagy	activates	pathway	0.90
Tau hyperphosphorylation	inhibits	process	0.90
Aβ accumulation	inhibits	process	0.90
AMPK	activates	protein	0.90
TFEB Nuclear Translocation	mediates	mechanism	0.88
Oxidative Stress	treats	disease	0.85
GSK3B	activates	gene	0.85
Neuroinflammation	inhibits	process	0.80
LC3	contributes_to	protein	0.80
OXIDATIVE STRESS	suppresses	process	0.75
KL	modulates	gene	0.75
ASTROCYTES	protects_against	cell_type	0.70
ASTROCYTES	activates	cell_type	0.70
cerebral ischemia/reperfusion injury	treats	disease	0.70
NRF2	activates	protein	0.70
AQP4	protects_against	gene	0.65
BDNF	regulates	gene	0.65
ISCHEMIA	activates	disease	0.65
TAU	inhibits	protein	0.65
HDAC2	inhibits	gene	0.65
AQP4	regulates	gene	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
BDNF	activates	gene	0.65
BDNF	phosphorylates	gene	0.65
BDNF	associated_with	gene	0.65
BDNF	expressed_in	gene	0.55
NRF2	associated_with	gene	0.50
MAPK	associated_with	gene	0.50
ASTROCYTES	associated_with	cell_type	0.50
ASTROCYTE	associated_with	cell_type	0.50
AUTOPHAGY	associated_with	phenotype	0.50
KEAP1	associated_with	gene	0.50
HMOX1	associated_with	gene	0.50
LAMP1	associated_with	gene	0.50
MTOR	associated_with	gene	0.50
HO-1	associated_with	gene	0.50
TFEB	associated_with	gene	0.50
ROS	associated_with	phenotype	0.50
RESVERATROL	associated_with	drug	0.45
TGFB1	associated_with	gene	0.45
HMGB1	associated_with	gene	0.45
STING	associated_with	gene	0.45
TREM2	associated_with	gene	0.45
CURCUMIN	associated_with	drug	0.45
SIRT1	associated_with	gene	0.45
NEURONS	associated_with	cell_type	0.45
ALZHEIMER	associated_with	disease	0.45
AKT	associated_with	gene	0.45

Incoming (17)

Source	Relation	Type	Str
h-5050522d	targets	hypothesis	1.00
OXIDATIVE STRESS	associated_with	phenotype	0.50
ATHEROSCLEROSIS	associated_with	disease	0.50
ALZHEIMER'S DISEASE	associated_with	disease	0.45
CURCUMIN	associated_with	drug	0.45
HMGB1	associated_with	gene	0.45
RESVERATROL	associated_with	drug	0.45
SIRT1	associated_with	gene	0.45
STING	associated_with	gene	0.45
BDNF	associated_with	gene	0.45
ALZHEIMER	associated_with	disease	0.45
NEURONS	associated_with	cell_type	0.45
AKT	associated_with	gene	0.45
CREB	associated_with	gene	0.45
ERK	associated_with	gene	0.45
HDAC2	associated_with	gene	0.45
N-ACETYLCYSTEINE	associated_with	drug	0.45

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sequential Iron Chelation (Deferoxamine) and GPX4 Restoratio	0.838	neurodegeneration	View

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SULFORAPHANE in their description or question text

No additional research found