gene

GLUL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLUL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

0Analyses

20Outgoing

8Incoming

0Experiments

0Debates

Summary

Gene profile: GLUL (Glutamate-Ammonia Ligase)

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🧬 Gene Info

Gene Symbol	GLUL
Full Name	Glutamine Synthetase
Aliases	Glutamate-Ammonia Ligase
Chromosome	1q31.3
Protein Type	Enzyme
Function	is a 392-amino acid enzyme that forms decameric complexes (10 subunits) in the cytosol.
Primary Expression	Astrocytes (highest), Oligodendrocytes, Neurons (low)
Molecular Weight	42 kDa
Amino Acids	392 aa
Pathways	Oxidative Stress
UniProt ID	P15104
NCBI Gene ID	2785
Ensembl ID	ENSG00000135821
OMIM	610012
GeneCards	GLUL
Human Protein Atlas	GLUL
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	ACSL4, BECN1, FTH1, GPX4, NCOA4, OXIDATIVE STRESS
KG Connections	28 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GLUL — AlphaFold P15104 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GLUL — Glutamine Synthetase

gene · 2324 words

→

GLUL Protein (Glutamine Synthetase)

protein · 1476 words

→

Pathway Diagram

flowchart TD
    GLUL(["GLUL"])
    TRIM25(["TRIM25"])
    Oxidative_Stress["Oxidative Stress"]
    OXIDATIVE_STRESS(["OXIDATIVE STRESS"])
    AND(["AND"])
    FOXO3(["FOXO3"])
    UBIQUITIN(["UBIQUITIN"])
    neurodegeneration["neurodegeneration"]

    GLUL -->|"activates"| TRIM25
    GLUL -->|"activates"| Oxidative_Stress
    OXIDATIVE_STRESS -->|"activates"| GLUL
    AND -->|"regulates"| GLUL
    FOXO3 -->|"regulates"| GLUL
    UBIQUITIN -->|"activates"| GLUL
    GLUL -->|"implicated in"| neurodegeneration

    style GLUL fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (20)

Target	Relation	Type	Str
Oxidative Stress	activates	pathway	0.60
POSTN	targets	gene	0.60
autophagy pathway	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
MAPK signaling	participates_in	pathway	0.60
senescence	participates_in	pathway	0.60
TRIM25	activates	gene	0.60
MAPK10	targets	gene	0.60
MAPT	targets	gene	0.60
SLC32A1	targets	gene	0.60
MAPK10	implicated_in	gene	0.60
MAPT	implicated_in	gene	0.60
SLC32A1	implicated_in	gene	0.60
SLC7A11	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
GPX4	activates	gene	0.60
NCOA4	activates	gene	0.60
SLC7A11	activates	gene	0.60
SQSTM1	activates	gene	0.60
ferroptosis	participates_in	pathway	0.60

Incoming (8)

Source	Relation	Type	Str
OXIDATIVE STRESS	activates	gene	0.60
AND	regulates	gene	0.60
MIRNAS	targets	gene	0.60
FOXO3	regulates	gene	0.60
UBIQUITIN	activates	gene	0.60
BECN1	interacts_with	gene	0.60
ACSL4	activates	gene	0.60
FTH1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GLUL in their description or question text

No additional research found