| Gene Symbol | PPP5C |
| Protein Family | Serine/Threonine Phosphatase Family |
| Protein Type | Serine/Threonine Phosphatase |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | various cancers - Cell Proliferation: Promotes cell cycle progression - Therapeutic Target: PP5 inhibitors are being explored as cancer therap |
| Subcellular Localization | Cytoplasm, Nucleus |
| Molecular Weight | 57 kDa |
| Amino Acids | 589 aa |
| Pathways | MAPK |
| UniProt ID | [P62937](https://www.uniprot.org/uniprot/P62937) |
| Ensembl ID | ENSG00000111454 |
| GeneCards | PPP5C |
| Human Protein Atlas | PPP5C |
| Autoinhibition | The TPR domain folds over and inhibits the phosphatase domain in the basal state |
| Activation | Binding to Hsp90 or other activators relieves autoinhibition |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | CCND1, CDKN1A, DUSP1, HSP90, NDRG2, SESN1 |
| KG Connections | 62 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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