protein

PGC-1ALPHA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PGC-1ALPHA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections

0Hypotheses

0Analyses

19Outgoing

36Incoming

0Experiments

0Debates

Summary

PGC-1α (PPARGC1A)

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🔬 Protein Info

Gene Symbol	PGC
Full Name	1ALPHA
Function	Pgc 1Α Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GeneCards	PGC
Human Protein Atlas	PGC
Known Drugs/Compounds	COENZYME Q10, METFORMIN, RAPAMYCIN, TREHALOSE
Interactions	BCL2, BECN1, CTSD, EGFR, FOXO1, GAPDH
KG Connections	51 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🔮 Predicted Structure: PGC-1ALPHA — AlphaFold Q9UBX2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    PGC_1ALPHA["PGC-1ALPHA"]
    PGC_1ALPHA -->|"activates"| mitochondrial_biogenesis["mitochondrial biogenesis"]
    PGC_1ALPHA -->|"activates"| nuclear_respiratory_factor_1["nuclear respiratory factor 1"]
    PGC_1ALPHA -->|"activates"| RAPAMYCIN["RAPAMYCIN"]
    PGC_1ALPHA -->|"activates"| SQSTM1["SQSTM1"]
    PGC_1ALPHA -->|"regulates"| ROS["ROS"]
    PGC_1ALPHA -->|"activates"| RAS["RAS"]
    PGC_1ALPHA -->|"activates"| TREHALOSE["TREHALOSE"]
    PGC_1ALPHA -->|"activates"| TFEB["TFEB"]
    PEROXISOME["PEROXISOME"] -->|"activates"| PGC_1ALPHA
    AMPK["AMPK"] -->|"regulates"| PGC_1ALPHA
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| PGC_1ALPHA
    LYSOSOME["LYSOSOME"] -->|"activates"| PGC_1ALPHA
    LAMP1["LAMP1"] -->|"activates"| PGC_1ALPHA
    MTOR["MTOR"] -->|"activates"| PGC_1ALPHA
    COENZYME_Q10["COENZYME Q10"] -->|"activates"| PGC_1ALPHA
    ISCHEMIA["ISCHEMIA"] -->|"activates"| PGC_1ALPHA

Outgoing (19)

Target	Relation	Type	Str
mitochondrial biogenesis	activates	pathway	0.80
nuclear respiratory factor 1	activates	protein	0.70
ROS	regulates	protein	0.50
RAPAMYCIN	activates	drug	0.50
SQSTM1	activates	gene	0.50
TFEB	activates	gene	0.35
SPINAL CORD	activates	brain_region	0.35
STEM CELLS	activates	cell_type	0.35
TDP-43	activates	gene	0.35
SOD1	activates	gene	0.35
SIRT1	expressed_in	gene	0.35
ROS	inhibits	protein	0.35
SIRT3	inhibits	gene	0.35
SIRT3	interacts_with	gene	0.35
ROS	activates	protein	0.35
PINK1	regulates	gene	0.35
TGF-BETA	regulates	gene	0.35
TREHALOSE	activates	drug	0.35
RAS	activates	gene	0.35

Incoming (36)

Source	Relation	Type	Str
SIRT1	associated_with	protein	0.90
AMPK	regulates	protein	0.70
LAMP1	activates	gene	0.50
MTOR	activates	gene	0.50
AUTOPHAGY	activates	process	0.50
P62	activates	gene	0.35
ALS	activates	disease	0.35
PARKINSON'S DISEASE	activates	disease	0.35
NEUROBLASTOMA	activates	disease	0.35
HUNTINGTON	activates	disease	0.35
GAPDH	activates	gene	0.35
BCL2	activates	gene	0.35
METFORMIN	expressed_in	drug	0.35
AMPK	expressed_in	gene	0.35
OXIDATIVE STRESS	inhibits	process	0.35
FOXO1	inhibits	gene	0.35
FOXO1	interacts_with	gene	0.35
BECN1	activates	gene	0.35
MITOPHAGY	regulates	process	0.35
CANCER	regulates	disease	0.35
MITOPHAGY	activates	process	0.35
NRF2	activates	gene	0.35
FIBROSIS	regulates	disease	0.35
OXIDATIVE PHOSPHORYLATION	activates	process	0.35
CANCER	activates	disease	0.35
HEPATOCELLULAR CARCINOMA	activates	disease	0.35
FERROPTOSIS	regulates	process	0.35
METFORMIN	inhibits	drug	0.35
ORGANOIDS	interacts_with	cell_type	0.35
HEPATOCELLULAR CARCINOMA	associated_with	disease	0.35
METFORMIN	therapeutic_target	drug	0.35
COENZYME Q10	activates	drug	0.35
ISCHEMIA	activates	disease	0.35
EGFR	activates	gene	0.35
CTSD	activates	gene	0.35
MYC	activates	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PGC-1ALPHA in their description or question text

No additional research found