gene

JAM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JAM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

42Connections

0Hypotheses

0Analyses

30Outgoing

12Incoming

0Experiments

0Debates

Summary

JAM2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, implicated in. Associated with ALS, Aging, Als. Connected to 25 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	JAM2
Full Name	Junctional Adhesion Molecule 2
Aliases	Page for JAM2
Function	JAM2 mediates homophilic (JAM2-JAM2) and heterophilic (JAM2-JAM3) interactions at cell junctions
Primary Expression	brain endothelial cells forming the blood-brain barrier, with lower expression in neurons (particularly in the [hippocampus](/bra
Ensembl ID	ENSG00000176182
GeneCards	JAM2
Human Protein Atlas	JAM2
Associated Diseases	Aging, Als, Ataxia, Ms, Parkinson
Interactions	CMPK2, MYORG, PDGFB, PDGFRB, SLC20A2, XPR1
KG Connections	42 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

JAM2 - Junctional Adhesion Molecule 2

gene · 509 words

→

Pathway Diagram

graph TD
    JAM2["JAM2"]
    Primary_Familial_Brain_Calcification{"Primary Familial Brain Calcification"}
    JAM2 -->|"associated with"| Primary_Familial_Brain_Calcification
    Aging{"Aging"}
    JAM2 -->|"associated with"| Aging
    Ms{"Ms"}
    JAM2 -->|"associated with"| Ms
    Parkinson{"Parkinson"}
    JAM2 -->|"associated with"| Parkinson
    Als{"Als"}
    JAM2 -->|"associated with"| Als
    Ataxia{"Ataxia"}
    JAM2 -->|"associated with"| Ataxia
    ALS{"ALS"}
    JAM2 -->|"associated with"| ALS
    PDGFRB["PDGFRB"]
    JAM2 -->|"associated with"| PDGFRB
    PDGFB["PDGFB"]
    JAM2 -->|"associated with"| PDGFB
    GENES["GENES"]
    JAM2 -->|"associated with"| GENES
    XPR1["XPR1"]
    JAM2 -->|"associated with"| XPR1
    SLC20A2["SLC20A2"]
    JAM2 -->|"associated with"| SLC20A2
    JUN["JUN"]
    JUN -->|"associated with"| JAM2
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    MITOCHONDRIAL_DYSFUNCTION -->|"associated with"| JAM2
    PDGFB -->|"associated with"| JAM2
    SLC20A2 -->|"associated with"| JAM2
    AND["AND"]
    AND -->|"associated with"| JAM2
    GENES -->|"associated with"| JAM2
    style JAM2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (30)

Target	Relation	Type	Str
Primary Familial Brain Calcification	causes	disease	0.95
Primary Familial Brain Calcification	associated_with	disease	0.95
Ataxia	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Als	associated_with	disease	0.65
MYORG	associated_with	gene	0.60
PDGFRB	associated_with	gene	0.60
MYORG	interacts_with	gene	0.60
SLC20A2	interacts_with	gene	0.60
XPR1	interacts_with	gene	0.60
Rb	associated_with	protein	0.60
OCLN	associated_with	gene	0.60
PDGFRB	interacts_with	gene	0.60
JUN	associated_with	gene	0.60
GENES	associated_with	gene	0.60
XPR1	associated_with	gene	0.60
SLC20A2	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
CMPK2	associated_with	gene	0.60
Pdgf	associated_with	protein	0.60
PDGFB	associated_with	gene	0.60
Cerebellum	expressed_in	brain_region	0.55
White Matter	expressed_in	brain_region	0.55
Thalamus	expressed_in	brain_region	0.55
PDGFB	interacts_with	gene	0.50

Incoming (12)

Source	Relation	Type	Str
CMPK2	associated_with	gene	0.60
MYORG	associated_with	gene	0.60
XPR1	associated_with	gene	0.60
CMPK2	interacts_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
SLC20A2	associated_with	gene	0.60
GENES	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
JUN	associated_with	gene	0.60
PDGFB	associated_with	gene	0.60
PDGFRB	associated_with	gene	0.60
PDGFRB	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning JAM2 in their description or question text

No additional research found