protein

P2Y12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P2Y12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

90Connections

4Hypotheses

2Analyses

50Outgoing

32Incoming

10Experiments

2Debates

Summary

P2Y12 is a protein involved in neurodegeneration research. Key relationships include: activates, targets, associated with. Associated with Chronic Kidney Disease, Diabetes Mellitus, Thrombosis. Connected to 13 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	P2Y12
Function	P2Y12 on microglia mediates response to amyloid-beta[@moorhead2019]. The receptor is involved in microglial recruitment to plaques. Genetic variants may affect AD risk.
Molecular Weight	39.4 kDa
Pathways	Pik3, PI3K pathway, purinergic signaling, synaptic plasticity, PI3K-AKT-mTOR signaling
GeneCards	P2Y12
Human Protein Atlas	P2Y12
Associated Diseases	ALS, Chronic Kidney Disease, diabetes, disease, epilepsy
Known Drugs/Compounds	P2Y12_inverse_agonists
Interactions	ALZHEIMER, AMYLOID, ATP, CD39, CD47, EPILEPSY
KG Connections	90 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    P2Y12["P2Y12"]
    Platelet_Aggregation["Platelet Aggregation"]
    P2Y12 -->|"activates"| Platelet_Aggregation
    Platelet["Platelet"]
    P2Y12 -->|"expressed_in"| Platelet
    Thrombosis{"Thrombosis"}
    P2Y12 -->|"involved_in"| Thrombosis
    ADCY["ADCY"]
    P2Y12 -.->|"inhibits"| ADCY
    cAMP["cAMP"]
    P2Y12 -.->|"downregulates"| cAMP
    Pik3["Pik3"]
    P2Y12 -->|"activates"| Pik3
    Adp["Adp"]
    Adp -->|"activates"| P2Y12
    Clopidogrel["Clopidogrel"]
    Clopidogrel -->|"targets"| P2Y12
    Ticagrelor["Ticagrelor"]
    Ticagrelor -->|"targets"| P2Y12
    style P2Y12 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (58)

Target	Relation	Type	Str
PI3K pathway	activates	pathway	0.80
purinergic signaling	participates_in	pathway	0.75
microglia	expressed_in	cell_type	0.75
Alzheimer's disease	regulates	disease	0.65
autophagy pathway	participates_in	pathway	0.60
cardiovascular disease	regulates	disease	0.60
epilepsy	associated_with	disease	0.60
diabetes	associated_with	disease	0.60
neurodegeneration	biomarker_for	disease	0.60
neurodegeneration	interacts_with	disease	0.60
ALS	associated_with	disease	0.60
glymphatic clearance	participates_in	pathway	0.60
multiple sclerosis	activates	disease	0.60
Alzheimer's disease	activates	disease	0.60
neuroinflammation	activates	disease	0.60
blood-brain barrier	participates_in	pathway	0.60
neurodegeneration	regulates	disease	0.55
neurons	expressed_in	cell_type	0.55
tauopathy	expressed_in	disease	0.55
PSP	activates	gene	0.55
unfolded protein response	participates_in	pathway	0.55
DAM microglia	expressed_in	cell_type	0.55
tauopathy	activates	disease	0.55
oxidative stress response	participates_in	pathway	0.55
Alzheimer's disease	inhibits	disease	0.55
astrocytes	expressed_in	cell_type	0.55
neurodegeneration	activates	disease	0.55
PSP	inhibits	gene	0.55
TREM2	activates	gene	0.55
tauopathy	regulates	disease	0.55
neuroinflammation	inhibits	disease	0.55
synaptic plasticity	participates_in	pathway	0.55
neuroinflammation	regulates	disease	0.55
PI3K	activates	gene	0.55
PI3K-AKT-mTOR signaling	participates_in	pathway	0.55
TMEM119	activates	gene	0.55
disease	associated_with	disease	0.50
atherosclerosis	regulates	disease	0.50
Chronic Kidney Disease	associated_with	disease	0.50
DIABETES	associated_with	disease	0.50
DIABETES MELLITUS	associated_with	concept	0.50
disease	interacts_with	disease	0.50
HAPLN1	associated_with	protein	0.50
GRM2	associated_with	gene	0.50
GLUTAMATE	associated_with	concept	0.50
Neuron	interacts_with	cell_type	0.50
Cortex	inhibits	brain_region	0.50
Cortex	interacts_with	brain_region	0.50
Oligodendrocyte	inhibits	cell_type	0.50
BRAIN INJURY	regulates	concept	0.50

Incoming (32)

Source	Relation	Type	Str
P2Y12_inverse_agonists	inhibits	drug	0.65
ATP	associated_with	gene	0.60
P2RY12	activates	gene	0.55
CD47	activates	gene	0.55
GFAP	activates	gene	0.55
ATP	activates	gene	0.55
P2X7	activates	gene	0.55
CD39	activates	gene	0.55
P2X7	inhibits	gene	0.55
microglia	inhibits	cell_type	0.50
EPILEPSY	interacts_with	gene	0.50
Autophagy	regulates	process	0.50
CCR5	associated_with	gene	0.50
CDH23	associated_with	gene	0.50
P2RY12	associated_with	gene	0.50
P2RY12	regulates	gene	0.50
P2Y12 RECEPTOR	regulates	protein	0.50
microglia	interacts_with	cell_type	0.50
P2Y12 RECEPTOR	interacts_with	protein	0.50
microglia	associated_with	cell_type	0.50
microglia	regulates	cell_type	0.50
P2Y12 RECEPTOR	expressed_in	protein	0.50
P2Y12 RECEPTOR	activates	protein	0.50
P2Y12 RECEPTOR	associated_with	protein	0.50
P2Y12 RECEPTOR	inhibits	protein	0.50
Neuroinflammation	activates	process	0.50
CX3CR1	regulates	gene	0.50
AMYLOID	activates	gene	0.50
GENES	co_discussed	gene	0.50
NMDA	activates	protein	0.50
PI3K	activates	protein	0.50
ATP	co_expressed_with	protein	0.50

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Purinergic P2Y12 Inverse Agonist Therapy	0.703	neurodegeneration	Synaptic pruning by microglia in early A
Microglial P2Y12-Dependent Territorial Segregation of Synapt	0.686	synaptic biology	What determines the selectivity of compl
Female Microglia Exhibit Reduced P2Y12 Expression Conferring	0.580	neuroinflammation	How do regional, age, and sex-dependent
P2X7/P2Y12 Purinergic Signaling Connects Aβ Aggregation to S	0.423	neurodegeneration	How do perivascular cells specifically r

Mentioning Analyses (2)

Scientific analyses that reference this entity

Microglial subtypes in neurodegeneration — friend vs foe

neurodegeneration | 2026-04-17 | 7 hypotheses Top: 0.685

Synaptic pruning by microglia in early AD

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
P2RY12 inhibition in atherosclerosis mouse model	validation	atherosclerosis	0.900	0.00	ApoE-deficient mice	proposed	N/A
VSMC cholesterol efflux and P2RY12 signaling	exploratory	atherosclerosis	0.900	0.00	cultured VSMCs	proposed	N/A
Leukocyte gene expression analysis in COVID-19 patients	exploratory	COVID-19	0.900	0.00	human leukocytes from COVID-19	proposed	N/A
P2RY12 regulation of autophagy in VSMCs	exploratory	atherosclerosis	0.900	0.00	cultured VSMCs	proposed	N/A
P2RY12-MTOR pathway interaction in VSMCs	exploratory	atherosclerosis	0.850	0.00	cultured VSMCs	proposed	N/A
In vivo autophagy modulation in atherosclerotic mice	validation	atherosclerosis	0.850	0.00	ApoE-deficient mice	proposed	N/A
s:** - GPR32 knockout in microglia should worsen neuroinflammation if	falsification	Neuroinflammation	0.400	0.50	cell_line	proposed	$80,000
Proposed experiment from debate on Synaptic pruning by microglia in ea	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$240,000
FTD Microglia Role: Protective vs Destructive Mechanism Study	validation	Neuroinflammation	0.400	0.50	human	proposed	$2,960,000
Purinergic Signaling Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (19)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Beyond Activation: Characterizing Microglial Functional Phenotypes. [PMID:34571885]	Lier J, Streit WJ, Bechmann I	Cells	2021	2
The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting auto [PMID:32160082]	Pi S, Mao L, Chen J, Shi H, Liu Y, Guo X	Autophagy	2021	2
Role of P2Y(12) Receptor in Thrombosis. [PMID:27628007]	Zhang Y, Zhang S, Ding Z	Adv Exp Med Biol	2017	1
P2 purinergic receptors in systemic lupus erythematosus: from experimental findi [PMID:41825304]	Renaudineau Y, Brooks W	Current opinion in immunology	2026	0
The Dual Role of P2RY12: Impact of Polymorphism and Expression on Ischemic Event [PMID:41903930]	Li J, Gong Z, Wang S, Gu J, Wu S, Pang J	Journal of thrombosis and haem	2026	0
Association of P2Y12 Polymorphisms With the Risk of Ischemic Stroke Subtypes. [PMID:41761998]	Wu C, Chen Y, Chen J, Wei X, Zhang Z	Revista de neurologia	2026	0
[Advantageous therapeutic pathways and mechanisms of Jianpi Huogu Formula in tre [PMID:41814722]	Li T, Zhang C, Jia Y, Chen WH, Lin N, Zh	Zhongguo Zhong yao za zhi = Zh	2026	0
Clopidogrel Administration Impairs Neurovascular Unit Recovery and Exacerbates A [PMID:41898413]	Paul M, Paul JW, Hinwood M, Hood RJ, Mar	International journal of molec	2026	0
Pan-cancer T cell atlas links a cellular stress response state to immunotherapy [PMID:37248301]	["Chu Y", "Dai E", "Li Y", "Han G", "Pei	Nature medicine	2023	0
Updates on systemic consequences of coeliac disease. [PMID:33199835]	Katri Kaukinen	Nature reviews. Gastroenterolo	2021	0
Immune-related adverse events predict responses to PD-1 blockade immunotherapy i [PMID:33890283]	["Lu L", "Xing K", "Wei W", "Ling Y", "L	International journal of cance	2021	0
Endogenous TLR2 ligand embedded in the catalytic region of human cysteinyl-tRNA [PMID:32461342]	["Cho S", "Kim S", "Lee Y", "Song E", "K	Journal for immunotherapy of c	2020	0
Assemblies of Perisomatic GABAergic Neurons in the Developing Barrel Cortex. [PMID:31780328]	["Modol L", "Bollmann Y", "Tressard T",	Neuron	2020	0
Blood from heparin tubes is an acceptable alternative to assess hematocrit deter [PMID:30903756]	Pekar Jean-David; Carpentier Thomas; Mab	Clinical chemistry and laborat	2019	0
A Unique Microglia Type Associated with Restricting Development of Alzheimer's D [PMID:28602351]	["Keren-Shaul H", "Spinrad A", "Weiner A	Cell	2017	0
An Unusual Presentation of Acute Appendicitis With Mobile Cecum Syndrome [PMID:25943697]	Jia-Yuh Jean; Hsu-Hung Tseng; Wen-Shih K	Pediatrics and neonatology	2015	0
Platelet P2Y12 receptor inhibition by thienopyridines: status and future. [PMID:19678800]	["Porto I", "Giubilato S", "De Maria G",	Expert opinion on investigatio	2009	0
Pten regulates neuronal arborization and social interaction in mice. [PMID:16675393]	["Kwon C", "Luikart B", "Powell C", "Zho	Neuron	2006	0
Randomized comparison of prasugrel (CS-747, LY640315), a novel thienopyridine P2 [PMID:15967851]	["Wiviott S", "Antman E", "Winters K", "	Circulation	2005	0

Debates (2)

Multi-agent debates referencing this entity

Analyze the spectrum of microglial activation states (DAM, homeostatic, inflamma

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

What are the mechanisms underlying synaptic pruning by microglia in early ad?

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning P2Y12 in their description or question text

No additional research found