| Gene Symbol | P2Y12 |
| Aliases | P2Y12PROTEIN |
| Function | P2Y12 on microglia mediates response to amyloid-beta[@moorhead2019]. The receptor is involved in microglial recruitment to plaques. Genetic variants may affect AD risk. |
| Subcellular Localization | the plasma membrane of microglial cells in the central nervous system, making it one of the most specific markers for mi |
| Molecular Weight | 39.4 kDa |
| Pathways | Pik3, PI3K pathway, purinergic signaling, synaptic plasticity, PI3K-AKT-mTOR signaling |
| GeneCards | P2Y12 |
| Human Protein Atlas | P2Y12 |
| P2RY12 gene | The genetic basis for P2Y12 protein synthesis |
| Microglial activation | Key process regulated by P2Y12 signaling |
| Purinergic signaling | Broader pathway involving nucleotide-receptor interactions |
| Neuroinflammation | Pathological consequence of dysregulated P2Y12 function |
| ADP/ATP signaling | Extracellular nucleotide pathways |
| G protein-coupled receptors | Protein |
| Associated Diseases | ALS, Chronic Kidney Disease, diabetes, disease, epilepsy |
| Known Drugs/Compounds | P2Y12_inverse_agonists |
| Interactions | ALZHEIMER, AMYLOID, ATP, CD39, CD47, EPILEPSY |
| KG Connections | 90 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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