cell 795 words KG: ent-gene-c3a6393f
Contents

P2Y12 Neurons

🔬 Protein Info
Gene Symbolent-gene-c3a6393f
Trigeminal GanglionFacial nociceptors
Nodose GanglionVagal afferents
Dorsal HornLamina I-II terminals
Substantia GelatinosaPain transmission neurons
ThalamusSensory relay nuclei
HypothalamusHomeostatic integration
P2RY12G protein-coupled ADP receptor
P2X3Co-expressed in some nociceptors
TRPV1Nociceptive marker
IB4Isolectin B4 binding (non-peptidergic)
CGRPPeptidergic marker
NF200Myelinated fiber marker
AgonistsADP, ATP, 2-MeSADP
AntagonistsClopidogrel, prasugrel, ticagrelor, ticlopidine
SignalingGi/o protein → decreased cAMP
KG Connections14 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

Wikipedia

Related Hypotheses (7)

Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53
...
Score: 0.68

Related Analyses (14)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (9)

Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.45
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45
Purinergic Signaling Dysfunction Validation in Parkinson's D
clinical · proposed · Score: 0.40
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
s:** - GPR32 knockout in microglia should worsen neuroinflam
falsification · proposed · Score: 0.40

Knowledge Graph (12 edges)

h-373fac84b5 targets ent-gene-c3a6393f
ent-gene-c3a6393f targeted_by h-373fac84b5
h-d3a2216a86 targets ent-gene-c3a6393f
ent-gene-c3a6393f data_in benchmark_ot_ad_answer_key:P2RY12
benchmark_ot_ad_answer_key:P2RY12 data_in ent-gene-c3a6393f
h-fdc381dee7 targets ent-gene-c3a6393f
ent-gene-c3a6393f targeted_by h-fdc381dee7
h-bb7f540f0f targets ent-gene-c3a6393f
ent-gene-c3a6393f targeted_by h-bb7f540f0f
h-e2878cf1a1 targets ent-gene-c3a6393f

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