gene 1,217 words KG: P2RY14
Contents

P2RY14 Gene - Purinergic Receptor P2Y14

🧬 Gene Info
Gene SymbolP2RY14
Full NamePurinergic Receptor P2Y14
AliasesPage for P2RY14 Gene
Chromosome3q25.1
Protein TypeReceptor
Functionencodes a G-protein coupled receptor that responds to UDP-sugars (particularly UDP-glucose, UDP-galactose, and UDP-N-acetylglucosamine) and mediates immune and inflammatory responses.
Primary Expressionimmune tissues and regulates:
Amino Acids336 aa
PathwaysPI3K
UniProt IDQ9HC97
NCBI Gene ID9939
GeneCardsP2RY14
Human Protein AtlasP2RY14
N-terminusExtracellular, glycosylation sites
Transmembrane domains7 α-helices crossing the membrane
Associated Diseasesneurodegeneration
KG Connections40 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (13)

Purinergic Signaling Polarization Control
Score: 0.71
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
Multi-Modal Stress Response Harmonization
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Microbial Inflammasome Priming Prevention
Score: 0.65
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53
Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.36

Related Analyses (10)

Synaptic pruning by microglia in early AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (11)

ATP P2X3 Receptor Neurons
cell · KG edge: expressed_in
Apoptosis in Neurodegeneration
entity · KG edge: expressed_in
FOS Gene
gene · KG edge: expressed_in
IGF1 Gene
gene · KG edge: expressed_in
MMP9 Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

P2RX1 therapeutic_target P2RY14
P2RX4 therapeutic_target P2RY14
P2RX7 therapeutic_target P2RY14
P2RY14 therapeutic_target P2RY1
P2RY1 therapeutic_target P2RY14
P2RY14 therapeutic_target P2RX7
PLIN1 expressed_in P2RY14
IGF1 expressed_in P2RY14
P2RY14 expressed_in MMP9
P2RY14 expressed_in FOS

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.