protein 1,724 words KG: P2RY13PROTEIN
Contents

P2RY13 Protein

🔬 Protein Info
Gene SymbolP2RY13
AliasesPurinergic Receptor P2Y13
Chromosome3q25.2
Protein TypeReceptor
Functionis a G protein-coupled receptor (GPCR) belonging to the P2Y receptor family that responds to extracellular nucleotides, particularly ATP and ADP.
Primary Expressionimmune cells, including microglia in the brain, where it plays a crucial role in modulating inflammatory re
Molecular Weight42 kDa
Amino Acids339 aa
PathwaysPI3K, MAPK pathway, NF-κB
Ensembl IDENSG00000144647
GeneCardsP2RY13
Human Protein AtlasP2RY13
Associated DiseasesAtherosclerosis, Cardiovascular, Ms
InteractionsCSF1R, CX3CR1, P2RY12, TMEM119
KG Connections19 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (15)

Purinergic Signaling Polarization Control
Score: 0.71
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
TREM2-Dependent Microglial Senescence Transition
Score: 0.54
Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.29

Related Analyses (7)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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