gene

P2RX5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P2RX5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

0Hypotheses

0Analyses

25Outgoing

20Incoming

0Experiments

0Debates

Summary

P2RX5 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, implicated in. Associated with ALS, Als, Covid. Connected to 27 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	P2RX5
Chromosome	17p13.1
Protein Type	Channel
Function	encodes a member of the P2X family of ATP-gated ion channels.
Primary Expression	various tissues including lymphoid organs, bladder, and parts of the nervous system, with roles in immune function, sensory signaling, and more recent
Amino Acids	422 aa
NCBI Gene ID	5026
GeneCards	P2RX5
Human Protein Atlas	P2RX5
Associated Diseases	Als, Inflammation
Interactions	adora2b, ADORA2B, AND, F3, GENES, P2RX1
KG Connections	45 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

P2RX5 Gene

gene · 1021 words

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Pathway Diagram

graph TD
    P2RX5["P2RX5"]
    Als{"Als"}
    P2RX5 -->|"associated with"| Als
    Inflammation{"Inflammation"}
    P2RX5 -->|"associated with"| Inflammation
    Covid{"Covid"}
    P2RX5 -->|"activates"| Covid
    ALS{"ALS"}
    P2RX5 -->|"associated with"| ALS
    PANX1["PANX1"]
    P2RX5 -->|"activates"| PANX1
    P2RY12["P2RY12"]
    P2RX5 -->|"activates"| P2RY12
    INFLAMMATION["INFLAMMATION"]
    P2RX5 -->|"associated with"| INFLAMMATION
    P2RX7["P2RX7"]
    P2RX5 -->|"activates"| P2RX7
    P2RX4["P2RX4"]
    P2RX5 -->|"activates"| P2RX4
    GENES["GENES"]
    P2RX5 -->|"activates"| GENES
    CD38["CD38"]
    P2RX5 -->|"associated with"| CD38
    ATP["ATP"]
    P2RX5 -->|"associated with"| ATP
    ADORA2B["ADORA2B"]
    ADORA2B -->|"activates"| P2RX5
    P2RY12 -->|"activates"| P2RX5
    P2RX1["P2RX1"]
    P2RX1 -->|"activates"| P2RX5
    P2RX4 -->|"activates"| P2RX5
    P2RX7 -->|"activates"| P2RX5
    CD38 -->|"associated with"| P2RX5
    P2RY1["P2RY1"]
    P2RY1 -->|"activates"| P2RX5
    PANX1 -->|"activates"| P2RX5
    GENES -->|"activates"| P2RX5
    ATP -->|"associated with"| P2RX5
    NAD["NAD"]
    NAD -->|"associated with"| P2RX5
    AND["AND"]
    AND -->|"activates"| P2RX5
    style P2RX5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (25)

Target	Relation	Type	Str
UPREGULATES	upregulates	entity	0.95
Covid	activates	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Als	associated_with	disease	0.65
P2RX1	activates	gene	0.60
P2RX7	regulates	entity	0.60
P2RY1	regulates	entity	0.60
P2RY12	regulates	entity	0.60
CD38	associated_with	gene	0.60
P2RY1	activates	gene	0.60
PANX1	regulates	entity	0.60
ADORA2B	activates	gene	0.60
INFLAMMATION	associated_with	gene	0.60
App	associated_with	protein	0.60
PANX1	activates	gene	0.60
P2RY12	activates	gene	0.60
P2RX7	activates	gene	0.60
P2RX4	activates	gene	0.60
GENES	activates	gene	0.60
ATP	associated_with	gene	0.60
NAD	associated_with	gene	0.60
GENE EXPRESSION	activates	concept	0.50
P2RY1	co_expressed_with	gene	0.50
P2RX7	co_expressed_with	gene	0.50

Incoming (20)

Source	Relation	Type	Str
NAD	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
AND	activates	gene	0.60
F3	activates	gene	0.60
ADORA2B	activates	gene	0.60
P2RY12	activates	gene	0.60
P2RX1	activates	gene	0.60
P2RX4	activates	gene	0.60
P2RX7	activates	gene	0.60
CD38	associated_with	gene	0.60
P2RY1	activates	gene	0.60
PANX1	activates	gene	0.60
ADORA2B	regulates	entity	0.60
P2RX1	regulates	entity	0.60
P2RX4	regulates	entity	0.60
ATP	associated_with	gene	0.60
GENES	activates	gene	0.60
P2RX1	co_expressed_with	gene	0.50
P2RX4	co_expressed_with	gene	0.50
adora2b	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning P2RX5 in their description or question text

No additional research found