gene 2,543 words KG: P2RY1
Contents

P2RY1 Gene

🧬 Gene Info
Gene SymbolP2RY1
Full NamePurinergic Receptor P2Y1
Chromosome19p13.2
Protein FamilyP2Y receptor family (GPCR)
Protein TypeGpcr
Target ClassGpcr
FunctionGPCR antagonists or agonists modulating purinergic signaling
Mechanism of ActionGPCR antagonists or agonists modulating purinergic signaling
DruggabilityLow (0.41)
Clinical StagePhase I
Molecular Weight41 kDa
Exons2
PathwaysSpontaneous Bursting Activity
UniProt IDP47900
NCBI Gene ID5028
Ensembl IDENSG00000142203
OMIM181010
GeneCardsP2RY1
Human Protein AtlasP2RY1
Associated DiseasesAls, ALZHEIMER, DIABETES, epilepsy
Known Drugs/CompoundsMRS2500
Interactionsadora2b, ADORA2B, ATP, F3, GENES, P2RX1
SciDEX TargetView Target Profile (2 clinical trials)
KG Connections222 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (26)

Purinergic Signaling Polarization Control
Score: 0.71
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Multi-Modal Stress Response Harmonization
Score: 0.76
CYP46A1 Overexpression Gene Therapy
Score: 0.73
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
Microbial Inflammasome Priming Prevention
Score: 0.65
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.36
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Related Analyses (11)

Synaptic pruning by microglia in early AD
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

Related Experiments (2)

Leukocyte gene expression analysis in COVID-19 patients
exploratory · proposed · Score: 0.90
P2RX7 variant rs1718119 association with glucose homeostasis
exploratory · proposed · Score: 0.90

See Also (12)

Astrocytes
cell · KG edge: associated_with
ATP P2X3 Receptor Neurons
cell · KG edge: activates
Astrocytes
entity · KG edge: associated_with
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: associated_with
ADORA2B Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

P2RY1 associated_with neurodegeneration
P2RY1 interacts_with P2RX7
P2RX7 interacts_with P2RY1
BMAL1 co_discussed P2RY1
HK2 co_discussed P2RY1
MIRO1 co_discussed P2RY1
P2RY1 co_discussed SOAT1
P2RY1 co_discussed KCNK2
P2RY1 co_discussed TET2
P2RY1 co_discussed PIEZO1

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