| Gene Symbol | PMS2 |
| Full Name | DNA Mismatch Repair Protein PMS2 |
| Chromosome | 7p22.1 |
| Function | The complex coordinates all downstream mismatch repair activities |
| Molecular Weight | 96 kDa |
| Amino Acids | 862 aa |
| Exons | 15 |
| Pathways | Dna Methylation, Epigenetic, oxidative stress response |
| UniProt ID | [P54278](https://www.uniprot.org/uniprot/P54278) |
| Ensembl ID | ENSG00000122512 |
| GeneCards | PMS2 |
| Human Protein Atlas | PMS2 |
| Structure | The PMS2-MLH1 complex forms the core of the MutLα heterodimer |
| Stoichiometry | 1:1 ratio of PMS2 to MLH1 |
| Stability | Complex formation is required for stability of both proteins |
| Associated Diseases | Als, Cancer, Colorectal Cancer, Gastric Cancer, Huntington, Ms |
| Interactions | APC, ARID1A, CACNA1G, CANCER, CDKN2A, DNA |
| KG Connections | 80 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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