Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ash1l: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ASH1L |
| Chromosome | 1q22 |
| Protein Type | Transferase |
| Function | Histone H3K36 methyltransferase |
| Amino Acids | 2964 aa |
| Exons | 28 |
| Pathways | Mapk, Mismatch Repair, Wnt, Epigenetic |
| Ensembl ID | ENSG00000116539 |
| GeneCards | ASH1L |
| Human Protein Atlas | ASH1L |
| Associated Diseases | Tourette syndrome, Fibrosis |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ASH1L["ASH1L"]
ASH1L -->|"activates"| NME1["NME1"]
ASH1L -->|"inhibits"| MMP["MMP"]
ASH1L -->|"upregulates"| STAC2["STAC2"]
ASH1L -->|"inhibits"| osteoclastogenesis["osteoclastogenesis"]
ASH1L -->|"inhibits"| miR_let_7b["miR-let-7b"]
ASH1L -->|"catalyzes"| H3K36me["H3K36me"]
ASH1L -->|"catalyzes"| H3K4me["H3K4me"]
ASH1L -->|"upregulates"| IGF_2["IGF-2"]
ASH1L_AS1["ASH1L-AS1"] -->|"interacts"| ASH1L| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ASH1L | data_in | dataset_row | 0.00 |
| NME1 | activates | gene | 0.80 |
| MMP | inhibits | protein | 0.80 |
| Tourette syndrome | associated_with | disease | 0.80 |
| STAC2 | upregulates | gene | 0.80 |
| osteoclastogenesis | inhibits | biological_process | 0.80 |
| miR-let-7b | inhibits | entity | 0.80 |
| H3K36me | catalyzes | entity | 0.80 |
| H3K4me | catalyzes | entity | 0.80 |
| IGF-2 | upregulates | gene | 0.80 |
| Cancer | expressed_in | disease | 0.65 |
| Colorectal Cancer | expressed_in | disease | 0.65 |
| Fibrosis | associated_with | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Mapk | expressed_in | pathway | 0.60 |
| Mismatch Repair | expressed_in | pathway | 0.60 |
| Wnt | expressed_in | pathway | 0.60 |
| Epigenetic | associated_with | pathway | 0.60 |
| Macrophage | associated_with | cell_type | 0.60 |
| Ras | activates | protein | 0.60 |
| PRDM2 | contributes_to | gene | 0.60 |
| EP300 | contributes_to | gene | 0.60 |
| DNA | expressed_in | gene | 0.60 |
| P53 | expressed_in | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| GENES | contributes_to | gene | 0.60 |
| ARID1A | contributes_to | gene | 0.60 |
| PI3K | expressed_in | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ASH1L | data_in | dataset_row | 0.00 |
| ASH1L-AS1 | interacts_with | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ash1l in their description or question text
No additional research found