gene 2,054 words KG: MS4A6E
Contents

MS4A6E Gene

🧬 Gene Info
Gene SymbolMS4A6E
Full NameMembrane Spanning 4-Domains A6E
Chromosome11q12.2.
Functionis a member of the MS4A gene family located on chromosome 11q12.
Primary Expressionmicroglia, the resident immune cells of the brain, where it plays critical roles in phagocytosis, lipid metabolism, and immun
Molecular Weight25 kDa
Amino Acids253 aa
UniProt IDQ9H3Y5
NCBI Gene ID9315
Ensembl IDENSG00000110079
OMIM606546
GeneCardsMS4A6E
Human Protein AtlasMS4A6E
Associated Diseasesneurodegeneration
InteractionsAPOE, CLU, CR1, MS4A4A, MS4A6A
KG Connections9 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (24)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Membrane Cholesterol Gradient Modulators
Score: 0.71
Orexin-Microglia Modulation Therapy
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
pg 1/2Next →

Related Analyses (6)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
nct05508789
clinical_trial · Pages share 4 hypotheses
MK-1167 Phase 2 AD Trial (MK-1167-008)
clinical · Pages share 4 hypotheses
A Placebo-Controlled, Double-Blind, Parallel-Group, 18-
clinical · Pages share 4 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 4 hypotheses

Knowledge Graph (9 edges)

APOE interacts_with MS4A6E
CLU interacts_with MS4A6E
CR1 interacts_with MS4A6E
MS4A4A interacts_with MS4A6E
MS4A6A interacts_with MS4A6E
MS4A6E provides_data_for ds-83b31ef18d49
MS4A6E data_in benchmark_ot_ad_answer_key:MS4A6E
benchmark_ot_ad_answer_key:MS4A6E data_in MS4A6E
ds-83b31ef18d49 data_in MS4A6E

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.