gene 3,294 words KG: MS4A4A
Contents

MS4A4A Gene — Membrane-Spanning 4-Domains A4A

🧬 Gene Info
Gene SymbolMS4A4A
Full NameMembrane-Spanning 4-Domains A4A
Chromosome11q12.2
Functionencodes a membrane protein expressed primarily in immune cells, particularly microglia and other myeloid cells.
Primary Expressionimmune cells, particularly microglia and other myeloid cells
Molecular Weight24 kDa
Amino Acids199 aa
Exons6
UniProt IDQ9H3Y1
NCBI Gene ID246213
Ensembl IDENSG00000166926
OMIM614508
GeneCardsMS4A4A
Human Protein AtlasMS4A4A
Associated DiseasesAlzheimer's disease, Cancer
InteractionsAND, APOE, CLU, CR1, MS4A, MS4A6A
KG Connections54 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (14)

Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Membrane Cholesterol Gradient Modulators
Score: 0.71
Orexin-Microglia Modulation Therapy
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58
Lysosomal Membrane Repair Enhancement
Score: 0.54

Related Analyses (8)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (10)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: protects_against
Microglia in Neurodegeneration
entity · KG edge: causes
Complement System Dysregulation in Neurodegeneration -
gap · KG edge: associated_with
CCR8 Gene
gene · KG edge: associated_with
CD163 (Hemoglobin Scavenger Receptor)
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TREM2 expressed_in MS4A4A
MS4A4A associated_with CCR8
MS4A4A associated_with LAG3
MS4A4A associated_with TGFB1
MS4A4A associated_with FOXP3
MS4A4A associated_with CD163
MS4A4A associated_with STAT5B
MS4A4A associated_with Il-6
MS4A4A associated_with Stat3
MS4A4A interacts_with MS4A6A

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