concept

LNCRNA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LNCRNA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

289Connections

29Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	LNCRNA
Key Genes/Proteins	ABCA7, Actin, Akt, ALZHEIMER, ALZHEIMER'S DISEASE, Amyloid
Related Diseases	Als, ALS, Alzheimer, Amyotrophic Lateral Sclerosis
Related Pathways	Apoptosis

Pathway Diagram

graph TD
    LNCRNA["LNCRNA"]
    style LNCRNA fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    LNCRNA -->|"involved_in"| Cancer_Initiation["Cancer Initiation"]
    LNCRNA -->|"involved_in"| Cancer_Development["Cancer Development"]
    LNCRNA -->|"regulates"| Chromatin_Organization["Chromatin Organization"]
    LNCRNA -->|"regulates"| Transcriptional_Regulation["Transcriptional Regulation"]
    LNCRNA -->|"regulates"| Post_transcriptional_Regulatio["Post-transcriptional Regulation"]
    LNCRNA -->|"contributes to"| Tumor_Initiation["Tumor Initiation"]
    LNCRNA -->|"contributes to"| Tumor_Growth["Tumor Growth"]
    LNCRNA -->|"contributes to"| Metastasis["Metastasis"]
    INFLAMMATION([INFLAMMATION]) -->|"activates"| LNCRNA
    GAP43([GAP43]) -->|"activates"| LNCRNA
    RNA([RNA]) -->|"activates"| LNCRNA
    AND([AND]) -->|"activates"| LNCRNA
    LOC100911717([LOC100911717]) -->|"activates"| LNCRNA
    DNA([DNA]) -->|"regulates"| LNCRNA
    MIR31HG([MIR31HG]) -->|"activates"| LNCRNA
    HUNTINGTON([HUNTINGTON]) -->|"activates"| LNCRNA

Outgoing (197)

Target	Relation	Type	Str
Programmed Cell Death	regulates	process	0.95
Cancer Development	involved_in	process	0.90
Cancer Initiation	involved_in	process	0.90
Transcriptional Regulation	regulates	process	0.85
Cancer Initiation	involved_in	disease	0.85
Chromatin Organization	regulates	process	0.85
Chromatin Organization	regulates	process	0.85
Post-transcriptional Regulation	regulates	process	0.85
Tumor Initiation	contributes_to	process	0.85
Transcriptional Regulation	regulates	process	0.85
Tumor Growth	contributes_to	process	0.85
Neurodegeneration	biomarker_for	process	0.85
ALZHEIMER'S DISEASE	biomarker_for	disease	0.85
Metastasis	contributes_to	process	0.85
APOPTOSIS	regulates	process	0.85
AUTOPHAGY	regulates	process	0.85
PARKINSON'S DISEASE	biomarker_for	disease	0.85
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.80
Dna	interacts_with	compound	0.80
Cancer Metastasis	involved_in	disease	0.80
Aging	biomarker_for	process	0.80
PROTEIN	interacts_with	protein	0.80
Alzheimer'S Disease	modulates	disease	0.80
Huntington's Disease	therapeutic_target	disease	0.80
Amyotrophic Lateral Sclerosis	modulates	disease	0.80
Huntington's Disease	modulates	disease	0.80
Rna	interacts_with	compound	0.80
Cancer Diagnosis	biomarker_for	process	0.75
Cancer Therapy	involved_in	process	0.70
Tumor	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Huntington	activates	disease	0.65
Als	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Parkinson	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Cardiovascular	regulates	disease	0.65
Inflammation	activates	disease	0.65
ALS	expressed_in	disease	0.65
Tumor	regulates	disease	0.65
Cancer	associated_with	disease	0.65
ALS	regulates	disease	0.65
Als	regulates	disease	0.65
Tumor	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Senescence	activates	disease	0.65
Alzheimer	regulates	disease	0.65

Incoming (92)

Source	Relation	Type	Str
MIR31HG	activates	gene	0.60
GJA1	therapeutic_target	gene	0.60
ALZHEIMER	associated_with	gene	0.60
FERROPTOSIS	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
DNA	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
PARKINSON	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
HUNTINGTIN	activates	gene	0.60
HUNTINGTON'S DISEASE	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
MYC	activates	gene	0.60
C-MYC	activates	gene	0.60
CDKN2B-AS1	activates	gene	0.60
CDKN2B	activates	gene	0.60
MIRNAS	therapeutic_target	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
CDKN2B-AS1	encodes	gene	0.60
RNA	therapeutic_target	gene	0.60
APOPTOSIS	associated_with	gene	0.60
SLC16A1	interacts_with	gene	0.60
DNA	regulates	gene	0.60
RNA	regulates	gene	0.60
HUNTINGTON	activates	gene	0.60
P2RX7	expressed_in	gene	0.60
HMOX1	expressed_in	gene	0.60
MIRNAS	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
GBM	interacts_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60
RNA	interacts_with	gene	0.60
MIR-1269	interacts_with	gene	0.60
SLC16A1-AS1	interacts_with	gene	0.60
CANCER	associated_with	gene	0.60
P16	regulates	gene	0.60
CANCER	activates	gene	0.60
RAF	activates	gene	0.60
NEAT1	activates	gene	0.60
TAU	therapeutic_target	gene	0.60
ALS	activates	gene	0.60
TAU	activates	gene	0.60
AMYLOID	activates	gene	0.60
IGF1	expressed_in	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
ROS	activates	gene	0.60

Targeting Hypotheses (29)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated	0.865	molecular neurobiology	View
METTL3-Mediated m6A Modification of lncRNA-0021 Regulates mi	0.759	molecular neurobiology	View
Seed-Proximal Asymmetric Duplex Stability Confers lncRNA-002	0.733	molecular neurobiology	View
hnRNPA2B1-Mediated Structural Remodeling Controls lncRNA-002	0.684	molecular neurobiology	View
Seed match plus local RNA structure jointly determine lncRNA	0.670	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp

Gamma-Entrained PV Interneuron Networks Enable Precision p-t	0.550	molecular neurobiology	View
A pre-organized hairpin or loop in lncRNA-0021 creates a hig	0.550	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp
Gamma-Entrained PV Interneurons Enable p-tau217-Guided Preci	0.547	molecular neurobiology	View
Cerebrospinal Fluid p-tau217-Guided Astrocyte-Derived Extrac	0.542	molecular neurobiology	View
Cerebrospinal NFL-Triggered Liposome Dosing Maximizes lncRNA	0.517	molecular neurobiology	View
RNA-binding proteins stabilize or gate the lncRNA-0021:mmu-m	0.497	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp
Structured Intronic Scaffold Regions in Enhancer-dilncRNAs E	0.489	molecular biology	What are the conserved secondary structu
Gamma-Entrained PV Interneurons Enable Precision p-tau217-Gu	0.464	molecular neurobiology	View
Alpha-Beta Oscillation Coupling Enhances lncRNA-9969-Mediate	0.460	molecular neurobiology	View
CSF Neurofilament Light Chain-Guided Astrocyte-Derived Extra	0.458	molecular neurobiology	View
CSF Neurofilament Light-Triggered Astrocyte-Derived Exosome	0.450	molecular neurobiology	View
Alpha-Beta Oscillation Entrainment Enhances lncRNA-9969-Medi	0.434	molecular neurobiology	View
Gamma-Entrained P-tau217 Biomarker Cascades Optimize lncRNA-	0.431	molecular neurobiology	View
Theta-Gamma Coupling Modulates lncRNA-9969-Mediated Mitochon	0.424	molecular neurobiology	View
Alpha-Theta Oscillation Modulation Enhances lncRNA-9969-Medi	0.421	molecular neurobiology	View
LncRNA-HDAC1 Complex Formation Locks Microglia in Primed Sta	0.400	developmental neurobiology	Do perinatal immune challenges create pe
A-to-I RNA editing modulates the lncRNA-0021 binding site an	0.387	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp
Plasma p-tau217-Triggered Exosome Dosing Maximizes lncRNA-00	0.323	molecular neurobiology	View
CREB1-Induced lncRNA-9969 Selectively Sequesters miR-6361 Th	0.000	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp
CREB1-Induced lncRNA-9969 Selectively Binds miR-6361 Through	0.000	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp
Theta-Alpha Oscillation Entrainment Enhances lncRNA-9969-Med	0.000	molecular neurobiology	View
Competitive endogenous RNA network modulates mmu-miR-6361 av	0.000	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp
Theta-Gamma Cross-Frequency Coupling Modulates lncRNA-9969 P	0.000	molecular neurobiology	View
Competitive endogenous RNA mechanism enables lncRNA-0021 to	0.000	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Autophagy receptor identification for stress granule elimination	exploratory	neurodegenerative diseases	0.900	0.00	cultured cells under arsenite	proposed	N/A

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Roles of NAD+ in Health and Aging. [PMID:37848251]	Lautrup S, Hou Y, Fang EF, Bohr VA	Cold Spring Harbor perspective	2024
The different autophagy degradation pathways and neurodegeneration. [PMID:35134347]	Fleming A, Bourdenx M, Fujimaki M, Karab	Neuron	2022
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559]	["Wan Huida", "Wang Qi", "Chen Xiuting",	Autophagy	2020
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559]	["Wan Huida", "Wang Qi", "Chen Xiuting",	Autophagy	2020
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive defi [PMID:30742114]	Unknown	Nature neuroscience	2019

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LNCRNA in their description or question text

Gamma-Entrained PV Interneuron Networks Enable Precision p-tau217-Guided lncRNA

Score: 0.550 · molecular neurobiology · 2026-04-20

## Mechanistic Overview Gamma-Entrained PV Interneuron Networks Enable Precision p-tau217-Guided lncRNA Exosome Therapy

A pre-organized hairpin or loop in lncRNA-0021 creates a high-affinity docking s

Score: 0.550 · molecular neurobiology · 2026-04-25

lncRNA-0021 may contain a pre-folded structural element that lowers the entropic cost of binding and presents the miR-63

Gamma-Entrained PV Interneurons Enable p-tau217-Guided Precision Dosing of lncRN

Score: 0.547 · molecular neurobiology · 2026-04-17

## Mechanistic Overview Gamma-Entrained PV Interneurons Enable p-tau217-Guided Precision Dosing of lncRNA Therapeutics i

Cerebrospinal Fluid p-tau217-Guided Astrocyte-Derived Extracellular Vesicle Deli

Score: 0.542 · molecular neurobiology · 2026-04-17

## Mechanistic Overview Cerebrospinal Fluid p-tau217-Guided Astrocyte-Derived Extracellular Vesicle Delivery of lncRNA-0

Cerebrospinal NFL-Triggered Liposome Dosing Maximizes lncRNA-0021 Therapeutic Wi

Score: 0.517 · molecular neurobiology · 2026-04-20

## Mechanistic Overview Cerebrospinal NFL-Triggered Liposome Dosing Maximizes lncRNA-0021 Therapeutic Window in AD start

RNA-binding proteins stabilize or gate the lncRNA-0021:mmu-miR-6361 duplex

Score: 0.497 · molecular neurobiology · 2026-04-25

An auxiliary protein, such as TDP-43, FUS, or an hnRNP family member, may bind lncRNA-0021 and/or mmu-miR-6361 to increa

Structured Intronic Scaffold Regions in Enhancer-dilncRNAs Enable Cell-Type Sele

Score: 0.489 · molecular biology · 2026-04-21

## Mechanistic Overview Structured Intronic Scaffold Regions in Enhancer-dilncRNAs Enable Cell-Type Selective Targeting

Gamma-Entrained PV Interneurons Enable Precision p-tau217-Guided lncRNA Exosome

Score: 0.464 · molecular neurobiology · 2026-04-21

## Mechanistic Overview Gamma-Entrained PV Interneurons Enable Precision p-tau217-Guided lncRNA Exosome Therapy in Early

Alpha-Beta Oscillation Coupling Enhances lncRNA-9969-Mediated Autophagy Through

Score: 0.460 · molecular neurobiology · 2026-04-21

## Mechanistic Overview Alpha-Beta Oscillation Coupling Enhances lncRNA-9969-Mediated Autophagy Through SST Interneuron-

CSF Neurofilament Light Chain-Guided Astrocyte-Derived Extracellular Vesicle Del

Score: 0.458 · molecular neurobiology · 2026-04-21

## Mechanistic Overview CSF Neurofilament Light Chain-Guided Astrocyte-Derived Extracellular Vesicle Delivery of lncRNA-

CSF Neurofilament Light-Triggered Astrocyte-Derived Exosome Dosing Maximizes lnc

Score: 0.450 · molecular neurobiology · 2026-04-21

## Mechanistic Overview CSF Neurofilament Light-Triggered Astrocyte-Derived Exosome Dosing Maximizes lncRNA-0021 Therape

Alpha-Beta Oscillation Entrainment Enhances lncRNA-9969-Mediated Mitochondrial B

Score: 0.434 · molecular neurobiology · 2026-04-17

## Mechanistic Overview Alpha-Beta Oscillation Entrainment Enhances lncRNA-9969-Mediated Mitochondrial Biogenesis Throug

Gamma-Entrained P-tau217 Biomarker Cascades Optimize lncRNA-9969 Exosome Therapy

Score: 0.431 · molecular neurobiology · 2026-04-21

## Mechanistic Overview Gamma-Entrained P-tau217 Biomarker Cascades Optimize lncRNA-9969 Exosome Therapy Precision in Ea

Theta-Gamma Coupling Modulates lncRNA-9969-Mediated Mitochondrial Biogenesis Thr

Score: 0.424 · molecular neurobiology · 2026-04-21

## Mechanistic Overview Theta-Gamma Coupling Modulates lncRNA-9969-Mediated Mitochondrial Biogenesis Through SST Interne

Alpha-Theta Oscillation Modulation Enhances lncRNA-9969-Mediated Autophagy Throu

Score: 0.421 · molecular neurobiology · 2026-04-20

## Mechanistic Overview Alpha-Theta Oscillation Modulation Enhances lncRNA-9969-Mediated Autophagy Through SST Interneur