gene

LRP1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRP1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

101Connections

0Hypotheses

0Analyses

50Outgoing

31Incoming

0Experiments

0Debates

Summary

Gene: LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

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🧬 Gene Info

Gene Symbol	LRP1B
Full Name	Low Density Lipoprotein Receptor-Related Protein 1B
Aliases	Page for LRP1B Protein
Chromosome	2q22.1
Protein Type	Protein
Function	is a very large LDL receptor-family transmembrane protein that functions as an endocytic and signaling regulator in epithelial and neuronal systems.
Molecular Weight	500 kDa
Amino Acids	595 aa
Exons	92
Pathways	MAPK, PI3K, Wnt signaling
UniProt ID	Search UniProt
GeneCards	LRP1B
Human Protein Atlas	LRP1B
Associated Diseases	Aging, Als, Atherosclerosis, cancer
Interactions	APOE, APOPTOSIS, CANCER, LDL, PAH, PD-1
KG Connections	100 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: LRP1B — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LRP1B["LRP1B"]
    Cancer{"Cancer"}
    LRP1B -->|"associated with"| Cancer
    Neurodegeneration{"Neurodegeneration"}
    LRP1B -->|"associated with"| Neurodegeneration
    Cardiovascular{"Cardiovascular"}
    LRP1B -->|"associated with"| Cardiovascular
    Als{"Als"}
    LRP1B -->|"associated with"| Als
    Aging{"Aging"}
    LRP1B -->|"associated with"| Aging
    Hypertension{"Hypertension"}
    LRP1B -->|"associated with"| Hypertension
    Atherosclerosis{"Atherosclerosis"}
    LRP1B -->|"associated with"| Atherosclerosis
    Stroke{"Stroke"}
    LRP1B -->|"associated with"| Stroke
    Ms{"Ms"}
    LRP1B -->|"associated with"| Ms
    Heart_Failure{"Heart Failure"}
    LRP1B -->|"associated with"| Heart_Failure
    Ftd{"Ftd"}
    LRP1B -->|"associated with"| Ftd
    ALS{"ALS"}
    LRP1B -->|"associated with"| ALS
    LRP8["LRP8"]
    LRP8 -->|"associated with"| LRP1B
    LRP5["LRP5"]
    LRP5 -->|"associated with"| LRP1B
    LRP1["LRP1"]
    LRP1 -->|"associated with"| LRP1B
    LRP2["LRP2"]
    LRP2 -->|"associated with"| LRP1B
    LDLR["LDLR"]
    LDLR -->|"associated with"| LRP1B
    LDL["LDL"]
    LDL -->|"associated with"| LRP1B
    STROKE["STROKE"]
    STROKE -->|"associated with"| LRP1B
    LRP4["LRP4"]
    LRP4 -->|"associated with"| LRP1B
    PAH["PAH"]
    PAH -->|"associated with"| LRP1B
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"associated with"| LRP1B
    CANCER["CANCER"]
    CANCER -->|"associated with"| LRP1B
    REELIN["REELIN"]
    REELIN -->|"associated with"| LRP1B
    style LRP1B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (70)

Target	Relation	Type	Str
Pulmonary Arterial Hypertension	associated_with	disease	0.80
Cancer	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Tumor	activates	disease	0.65
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Hypertension	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Heart Failure	associated_with	disease	0.65
Ftd	associated_with	disease	0.65
Atherosclerosis	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Heart Failure	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Hypertension	activates	disease	0.65
P53	associated_with	protein	0.60
REELIN	associated_with	gene	0.60
Lipid Metabolism	activates	pathway	0.60
Wnt	activates	pathway	0.60
RNA	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
Egfr	associated_with	protein	0.60
Oxidative Phosphorylation	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
LDL	associated_with	gene	0.60
Endothelial	associated_with	cell_type	0.60
Monocyte	associated_with	cell_type	0.60
TTN	associated_with	gene	0.60
RYR2	associated_with	gene	0.60
LRP2	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
MUC16	associated_with	gene	0.60
Lipid Metabolism	associated_with	pathway	0.60
Wnt	associated_with	pathway	0.60
AGING	associated_with	gene	0.60
Oxidative Phosphorylation	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
App	associated_with	protein	0.60
LRP5	associated_with	gene	0.60
LRP1	associated_with	gene	0.60
LRP8	associated_with	gene	0.60
ATRX	associated_with	gene	0.60
PI3K	associated_with	gene	0.60

Incoming (31)

Source	Relation	Type	Str
PAH	activates	gene	0.60
RYR2	associated_with	gene	0.60
AND	associated_with	gene	0.60
WNT	activates	gene	0.60
CANCER	activates	gene	0.60
LDLR	associated_with	gene	0.60
RNA	therapeutic_target	gene	0.60
LRP4	associated_with	gene	0.60
PAH	associated_with	gene	0.60
REELIN	associated_with	gene	0.60
LDL	associated_with	gene	0.60
STROKE	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
AGING	associated_with	gene	0.60
GENES	associated_with	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
TTN	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
PD-1	activates	gene	0.60
RNA	activates	gene	0.60
LDL	activates	gene	0.60
LRP8	associated_with	gene	0.60
LRP5	associated_with	gene	0.60
LRP1	associated_with	gene	0.60
LRP2	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
TP53	associated_with	gene	0.60
APOE	activates	gene	0.60
APOER2	associated_with	gene	0.60
WNT	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LRP1B in their description or question text

No additional research found