gene 757 words KG: KCNQ2
Contents

KCNQ2

🧬 Gene Info
Gene SymbolKCNQ2
AliasesKv7.2
Chromosome20q13.33
Functionis a non-inactivating K+ current that activates at voltages near the threshold for action potential firing.
Primary ExpressionBrain (neurons throughout forebrain, highest in cortex, hippocampus, brainstem)
Molecular Weight95 kDa
Amino Acids844 aa
UniProt IDO43726
NCBI Gene ID3785
Ensembl IDENSG00000155085
OMIM121200
GeneCardsKCNQ2
Human Protein AtlasKCNQ2
Associated DiseasesAging
InteractionsCANCER, EGFR, ERK, RUNX1
KG Connections67 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (5)

APOE-Dependent Autophagy Restoration
Score: 0.85
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
Hypocretin-Neurogenesis Coupling Therapy
Score: 0.69
Optogenetic Control of Mitochondrial Transfer Networks
Score: 0.48

Related Analyses (12)

Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mitochondrial transfer between neurons and glia
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (5)

AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (6)

DHX9 — DEAH-Box Helicase 9
gene · KG edge: therapeutic_target
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: activates
HDAC2 Gene
gene · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: regulates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: causes

Knowledge Graph (12 edges)

DHX9 therapeutic_target KCNQ2
KCNT1 associated_with KCNQ2
KCNQ2 therapeutic_target SCN1A
KCNQ2 therapeutic_target MTOR
KCNQ2 therapeutic_target RELN
KCNQ2 regulates MECP2
KCNQ2 regulates HDAC2
KCNQ3 regulates KCNQ2
EGFR activates KCNQ2
HDAC2 regulates KCNQ2

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