gene

JARID2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JARID2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

12Outgoing

4Incoming

0Experiments

0Debates

Summary

JARID2 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, activates, implicated in. Associated with Als, Breast Cancer, Cancer. Connected to 17 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	JARID2
Full Name	Jumonji and AT-Rich Interaction Domain Containing 2
Chromosome	6p22.3
Function	encodes a catalytically dead Jumonji C (JmjC) domain protein that serves as an essential accessory subunit of Polycomb Repressive Complex 2 (PRC2).
Amino Acids	1246 aa
UniProt ID	Q92833
Ensembl ID	ENSG00000008083
OMIM	601594
GeneCards	JARID2
Human Protein Atlas	JARID2
Associated Diseases	neurodegeneration
Interactions	CANCER, CCS, FN1, JAK, STAT3, UBIQUITIN
KG Connections	16 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: JARID2 — AlphaFold Q92833 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

JARID2

gene · 1047 words

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Pathway Diagram

graph TD
    JARID2["JARID2"]
    Tumor{"Tumor"}
    JARID2 -->|"inhibits"| Tumor
    Prostate_Cancer{"Prostate Cancer"}
    JARID2 -->|"inhibits"| Prostate_Cancer
    Cancer{"Cancer"}
    JARID2 -->|"inhibits"| Cancer
    Als{"Als"}
    JARID2 -->|"inhibits"| Als
    Breast_Cancer{"Breast Cancer"}
    JARID2 -->|"inhibits"| Breast_Cancer
    UBIQUITIN["UBIQUITIN"]
    JARID2 -->|"inhibits"| UBIQUITIN
    JAK["JAK"]
    JARID2 -->|"inhibits"| JAK
    VIM["VIM"]
    JARID2 -->|"activates"| VIM
    Metastasis(["Metastasis"])
    JARID2 -->|"inhibits"| Metastasis
    Chaperone(["Chaperone"])
    JARID2 -->|"inhibits"| Chaperone
    Invasion(["Invasion"])
    JARID2 -->|"inhibits"| Invasion
    Jak_Stat(["Jak-Stat"])
    JARID2 -->|"inhibits"| Jak_Stat
    CCS["CCS"]
    CCS -->|"inhibits"| JARID2
    STAT3["STAT3"]
    STAT3 -->|"activates"| JARID2
    FN1["FN1"]
    FN1 -->|"activates"| JARID2

Outgoing (12)

Target	Relation	Type	Str
Breast Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Prostate Cancer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Invasion	inhibits	pathway	0.60
UBIQUITIN	inhibits	gene	0.60
Jak-Stat	inhibits	pathway	0.60
VIM	activates	gene	0.60
JAK	inhibits	gene	0.60
Metastasis	inhibits	pathway	0.60
Chaperone	inhibits	pathway	0.60

Incoming (4)

Source	Relation	Type	Str
CCS	inhibits	gene	0.60
STAT3	activates	gene	0.60
FN1	activates	gene	0.60
CANCER	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning JARID2 in their description or question text

No additional research found