gene

CD46

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD46: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

1Hypotheses

0Analyses

13Outgoing

2Incoming

0Experiments

0Debates

Summary

Page for CD46

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🧬 Gene Info

Gene Symbol	CD46
Chromosome	1q32.2
Function	The CD46 gene encodes membrane cofactor protein (MCP), a crucial complement regulatory protein expressed on all nucleated cells
Pathways	complement cascade, JAK-STAT signaling, NF-kB signaling
Ensembl ID	ENSG00000108539
GeneCards	CD46
Human Protein Atlas	CD46
Associated Diseases	neurodegeneration
Interactions	C3, CD55, CD59, IDE, JAK2, STAT3
KG Connections	15 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CD46

gene · 613 words

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Pathway Diagram

flowchart TD
    N0["CD46"]
    N1["C4B"]
    N1 -->|"regulated by"| N0
    N2["C3"]
    N2 -->|"inhibits"| N0
    N3["neurons"]
    N0 -->|"expressed in"| N3
    N4["CD55"]
    N0 -->|"activates"| N4
    N5["CD59"]
    N0 -->|"regulates"| N5
    N6["complement cascade"]
    N0 -->|"participates in"| N6

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
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    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
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    class N0 gene
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    class N6 pathway

Outgoing (13)

Target	Relation	Type	Str
neurons	expressed_in	cell_type	0.75
CD59	regulates	gene	0.65
CD55	activates	gene	0.65
CD55	regulates	gene	0.65
complement cascade	participates_in	pathway	0.55
STAT3	activates	gene	0.55
JAK-STAT signaling	participates_in	pathway	0.55
CD55	inhibits	gene	0.55
CD59	inhibits	gene	0.55
CD59	activates	gene	0.55
IDE	activates	gene	0.55
NF-kB signaling	participates_in	pathway	0.55
JAK2	activates	gene	0.55

Incoming (2)

Source	Relation	Type	Str
C4B	regulated_by	gene	0.80
C3	inhibits	gene	0.55

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Differential Complement Regulator Expression on Synaptic Mem	0.725	synaptic biology	What determines the selectivity of compl

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CD46 in their description or question text

No additional research found