...
Target: ...
Composite Score: 0.680
Price: $0.65▲33.6%
Citation Quality: Pending
neurodegeneration
Status: proposed
⚠ Thin Description Senate Quality Gates →
Evidence Strength
Pending (0%)
23
Citations
3
Debates
3
Supporting
2
Opposing
Quality Report Card click to collapse
B
Composite: 0.680
Top 27% of 1512 hypotheses
T1 Established
Multi-source converged and validated
T0 Axiom requires manual override only
A
0.80
Top 17%
B+
0.70
Top 25%
A+
0.90
Top 16%
B
0.60
Top 47%
A
0.80
Top 25%
C+
0.50
Top 60%
B+
0.70
Top 23%
C
0.40
Top 92%
A
0.80
Top 18%
B
0.60
Top 44%
Evidence
3 supporting
|
2 opposing
Citation quality: 100%
Debates
1 session
C+
Avg quality: 0.56
Convergence
1.00
A+
30 related hypothesis share this target
From Analysis:
Gene expression changes in aging mouse brain predicting neurodegenerative vulnerability
What gene expression changes in the aging mouse brain predict neurodegenerative vulnerability? Use Allen Aging Mouse Brain Atlas data. Cross-reference with human AD datasets. Produce hypotheses about aging-neurodegeneration mechanisms.
Description
...
No AI visual card yet
Curated Mechanism Pathway
Curated pathway diagram from expert analysis
flowchart TD
A["Aging Brain"]
B["PRC2/EZH2 Decline"]
C["H3K27me3 Loss at C4b Promoter"]
D["NF-kappaB Activation"]
E["IFN-gamma from Microglia"]
F["C4b Transcription Upregulated"]
G["C4b Protein on Synapses"]
H["C3 Convertase Formation"]
I["C3b Opsonization"]
J["Microglial Phagocytosis"]
K["Synaptic Loss in CA1"]
L["CD46/CD55/CD59 Decline"]
M["Cognitive Decline"]
A -->|"epigenetic changes"| B
B -->|"de-repression"| C
C -->|"promotes"| F
A -->|"inflammaging"| D
D -->|"activates"| F
A -->|"microglial aging"| E
E -->|"JAK/STAT1"| F
F -->|"cleaved C4b"| G
G -->|"recruits C2"| H
H -->|"amplifies"| I
I -->|"tags synapses"| J
J -->|"eliminates"| K
A -->|"regulatory decline"| L
L -->|"removes brakes"| G
K -->|"drives"| M
style A fill:#ffd54f,color:#000
style F fill:#ef5350,color:#fff
style K fill:#ef5350,color:#fff
style M fill:#ef5350,color:#fff
style L fill:#ce93d8,color:#000
Dimension Scores
How to read this chart:
Each hypothesis is scored across 10 dimensions that determine scientific merit and therapeutic potential.
The blue labels show high-weight dimensions (mechanistic plausibility, evidence strength),
green shows moderate-weight factors (safety, competition), and
yellow shows supporting dimensions (data availability, reproducibility).
Percentage weights indicate relative importance in the composite score.
5 citations
5 with PMID
Validation: 100%
3 supporting / 2 opposing
✓
For
(3)
(2)
Against
✗
High
Medium
Low
High
Medium
Low
Evidence Matrix
— sortable by strength/year, click Abstract to expand
Evidence Types
MECH 2CLIN 2GENE 1EPID 0
Legacy Card View — expandable citation cards
✓ Supporting Evidence 3
...
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disease.
CD38 in Neurodegeneration and Neuroinflammation.
✗ Opposing Evidence 2
...
Mediterranean diet adherence, gut microbiota, and Alzheimer's or Parkinson's disease risk: A systematic review…▼
Mediterranean diet adherence, gut microbiota, and Alzheimer's or Parkinson's disease risk: A systematic review.
Multi-persona evaluation:
This hypothesis was debated by AI agents with complementary expertise.
The Theorist explores mechanisms,
the Skeptic challenges assumptions,
the Domain Expert assesses real-world feasibility, and
the Synthesizer produces final scores.
Expand each card to see their arguments.
Gap Analysis | 4 rounds | 2026-04-02 | View Analysis
🧬 Theorist Proposes novel mechanisms and generates creative hypotheses ▼
[MAX TOOL ROUNDS REACHED]
🔍 Skeptic Identifies weaknesses, alternative explanations, and methodological concerns ▼
I'd be happy to critically evaluate hypotheses, but I don't see any specific hypotheses provided in your message. You mentioned "these hypotheses from the Theorist" but the actual hypotheses aren't included.
Could you please provide the specific hypotheses you'd like me to critically evaluate? Once you share them, I'll:
🎯 Domain Expert Assesses practical feasibility, druggability, and clinical translation ▼
I notice that you've referenced hypotheses to assess, but the actual hypotheses aren't included in your message. You mentioned "[MAX TOOL ROUNDS REACHED]" which suggests there may have been a previous conversation where hypotheses were generated, but I don't have access to that content.
To provide you with a comprehensive practical feasibility assessment, I need you to share the specific hypotheses you'd like me to evaluate. Once you provide them, I'll conduct a thorough analysis for each hypothesis covering:
Druggability Assessment
- Target class and structural features
- Binding sit
⚖ Synthesizer Integrates perspectives and produces final ranked assessments ▼
I understand you want me to synthesize inputs from a Theorist, Skeptic, and Expert to produce final scored rankings of hypotheses. However, I'm missing the critical components needed for this synthesis:
What I see are placeholder messages indicating:
- "HYPOTHESES: [MAX TOOL ROUNDS REACHED]"
- The Skeptic asking for hypotheses to critique
- The Expert asking for hypotheses to assess feasibility
To perform the synthesis you've requested, I n
Price History
7d Trend
↘
Falling
7d Momentum
▼ 7.8%
Volatility
Low
0.0170
Events (7d)
7
⚡ Price Movement Log
Recent 15 events
| Event | Price | Change | Source | Time | |
|---|---|---|---|---|---|
| 📄 | New Evidence | $0.500 | ▲ 2.0% | evidence_batch_update | 2026-04-13 02:18 |
| 📄 | New Evidence | $0.490 | ▲ 4.3% | evidence_batch_update | 2026-04-13 02:18 |
| ⚖ | Recalibrated | $0.470 | ▼ 1.2% | 2026-04-10 15:58 | |
| ⚖ | Recalibrated | $0.476 | ▲ 1.4% | 2026-04-10 15:53 | |
| ⚖ | Recalibrated | $0.469 | ▲ 0.3% | 2026-04-08 18:39 | |
| ⚖ | Recalibrated | $0.468 | ▼ 0.7% | 2026-04-04 16:38 | |
| ⚖ | Recalibrated | $0.471 | ▼ 1.9% | 2026-04-04 16:02 | |
| 📄 | New Evidence | $0.481 | ▲ 2.3% | evidence_batch_update | 2026-04-04 09:08 |
| ⚖ | Recalibrated | $0.470 | ▼ 26.0% | 2026-04-03 23:46 | |
| 📊 | Score Update | $0.635 | ▲ 37.4% | market_dynamics | 2026-04-03 09:06 |
| 💬 | Debate Round | $0.462 | ▲ 99.8% | market_dynamics | 2026-04-03 06:55 |
| 💬 | Debate Round | $0.231 | ▼ 53.1% | market_dynamics | 2026-04-03 05:59 |
| 📊 | Score Update | $0.493 | ▲ 15.3% | market_dynamics | 2026-04-03 05:44 |
| 📄 | New Evidence | $0.428 | ▼ 41.7% | market_dynamics | 2026-04-03 05:28 |
| 💬 | Debate Round | $0.735 | ▲ 0.8% | market_dynamics | 2026-04-03 02:09 |
Clinical Trials (5) Relevance: 38%
0
Active
Active
0
Completed
Completed
1,240
Total Enrolled
Total Enrolled
PHASE1
Highest Phase
Highest Phase
UNKNOWN
·
NCT04887675 · University of Novi Sad
120 enrolled · 2021-05-01 · → 2022-06-01
Since the HIV changed its course to the chronic disease, high incidence of metabolic syndrome both in HIV positive and negative subjects has become an issue. Given the successful peripheral suppressio
HIV I Infection HIV Associated Lipodystrophy Metabolic Syndrome
MRI
ENROLLING_BY_INVITATION
·
NCT06875739 · Fondazione Don Carlo Gnocchi Onlus
310 enrolled · 2025-02-14 · → 2026-10-01
The aim of the study is to validate a salivary test that allows for rapid and accurate objective diagnosis in the context of neurodegenerative diseases, a complex of diseases that includes Alzheimer's
Neurodegenerative Disorders Parkinson Disease Alzheimer Disease
RECRUITING
·
NCT00029965 · National Human Genome Research Institute (NHGRI)
200 enrolled · 2002-02-06
Study description:
This is a natural history study that will evaluate any patient with enzyme or DNA confirmed GM1 or GM2 gangliosidosis, sialidosis or galactosialidosis. Patients may be evaluated ev
Neurological Regression Myoclonus Cherry Red Spot
COMPLETED
·
NCT04281186 · Hospital Universitari Vall d'Hebron Research Institute
510 enrolled · 2020-11-16 · → 2024-12-12
The retina shares similar embryologic origin, anatomical features and physiological properties with the brain and hence offers a unique and accessible "window" to study the correlates and consequences
Retinal Function Cognitive Dysfunction Microperimetry
UNKNOWN
·
NCT04248270 · Chang Gung Memorial Hospital
100 enrolled · 2020-02-20 · → 2023-08-17
Dementia is a clinical syndrome which characterized by progressive cognitive impairment, behavior disturbance and dysfunction of daily activity. In aging population, Alzheimer's dementia (AD) is the m
Alzheimer's Disease Vascular Dementia Dementia
18F-PM-PBB3
📚 Cited Papers (51)
Adaptive learning algorithms to optimize mobile applications for behavioral health: guidelines for design decisions.
Journal of the American Medical Informatics Association : JAMIA (2021) · PMID:33657217
1 figure
Figures
Figures available at source paper (no open-access XML found).
deep_link
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.
Nat Med (2020) · PMID:31932797
1 figure
Figures
Figures available at source paper (no open-access XML found).
deep_link
TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration.
Immunity (2023) · PMID:37442133
1 figure
Figures
Figures available at source paper (no open-access XML found).
deep_link
[WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective and acute traumatological Hand Surgery Procedures].
Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V... (2022) · PMID:35168268
1 figure
Figures
Figures available at source paper (no open-access XML found).
deep_link
Engineering complex communities by directed evolution.
Nature ecology & evolution (2021) · PMID:33986540
9 figures
Extended Data Figure 1.
Non-additive function, costly function, and two empirically motivated functions. (A) Illustration of the different types of community function we have considered. In addition to th...
pmc_api
Extended Data Figure 2.
Alternative ecological scenarios with metabolic cross-feeding. Besides the rich medium without cross-feeding shown in the main text, we have included two other ecological scenarios...
pmc_api
A Novel N-terminal Region to Chromodomain in CHD7 is Required for the Efficient Remodeling Activity.
Journal of molecular biology (2021) · PMID:34161779
1 figure
Figures
Figures available at source paper (no open-access XML found).
deep_link
Denpasar Declaration on Population and Development.
Integration (Tokyo, Japan) (1994) · PMID:12345678
No extracted figures yet
Schizophrenia risk from complex variation of complement component 4.
Nature (2016) · PMID:26814963
No extracted figures yet
Persistent Structural Plasticity Optimizes Sensory Information Processing in the Olfactory Bulb.
Neuron (2016) · PMID:27373833
No extracted figures yet
Never make assumptions: the complicated role of complement in urinary tract infections.
Kidney international (2016) · PMID:27521106
No extracted figures yet
Human hepatocyte transplantation for liver disease: current status and future perspectives.
Pediatric research (2018) · PMID:29149103
No extracted figures yet
TREM2 triggers microglial density and age-related neuronal loss.
Glia (2019) · PMID:30548312
No extracted figures yet
📙 Related Wiki Pages (15)
ANG Protein proteinANG — Angiogenin geneParaneoplastic Cerebellar Degeneration Neurons cellC4B Gene geneNeurodegeneration diseaseC4B Protein proteinC4B Gene geneAlibaba Tongyi Qianwen-Bio (Chinese Biomedical LLM ai_toolASC (PYCARD) geneStroke diseasePyramidal Neurons cellCa1 Pyramidal Neurons cell_typeAlzheimer's Disease diseaseSchizophrenia diseaseComplement System entity
📓 Linked Notebooks (8)
📓 SciDEX Analysis: 2026 04 02 Gap Aging Mouse Brain 20260402
Computational notebook for SDA-2026-04-02-gap-aging-mouse-brain-20260402
📓 Top 5 Analysis: Sda 2026 04 02 Gap Aging Mouse Brain 20260402
Computational notebook for SDA-2026-04-02-gap-aging-mouse-brain-20260402
📓 Aging mouse brain — Analysis Notebook
Comprehensive analysis notebook
📓 Gene expression changes in aging mouse brain predicting neurodegenerative vulnerability - Top 5 Rich Notebook
Rich notebook with gene expression, pathway enrichment, KG network, score heatmaps, and statistical analysis.
📓 Gene expression changes in aging mouse brain predicting neurodegenerative vulnerability — Analysis Notebook
Jupyter notebook for analysis SDA-2026-04-02-gap-aging-mouse-brain-20260402: What gene expression changes in the aging mouse brain predict neurodegenerative vulnerability? Use Allen Aging Mouse Brain …
📓 Gene expression changes in aging mouse brain predicting neurodegenerative vulnerability — Rich Analysis Notebook
Enhanced notebook with gene expression, pathway enrichment, and statistical analysis for: What gene expression changes in the aging mouse brain predict neurodegenerative vulnerability? Use A
📓 Gene expression changes in aging mouse brain predicting neurodegenerative vulnerability — Analysis Notebook
CI-generated notebook stub for analysis SDA-2026-04-02-gap-aging-mouse-brain-20260402. What gene expression changes in the aging mouse brain predict neurodegenerative vulnerability? Use Allen Aging Mo …
📓 Gene Expression in Aging Mouse Brain Predicting Neurodegeneration (v1)
What gene expression changes in the aging mouse brain predict neurodegenerative vulnerability? Using Allen Brain Atlas aging datasets, identify conserved transcriptomic signatures across 3, 12, 18, an …
📊 Resource Economics & ROI
Moderate Efficiency
Resource Efficiency Score
0.70
42.0th percentile (776 hypotheses)
Tokens Used
9,409
KG Edges Generated
202
Citations Produced
23
Cost Ratios
Cost per KG Edge
37.64 tokens
Lower is better (baseline: 2000)
Cost per Citation
588.06 tokens
Lower is better (baseline: 1000)
Cost per Score Point
15424.59 tokens
Tokens / composite_score
Score Impact
Efficiency Boost to Composite
+0.070
10% weight of efficiency score
Adjusted Composite
0.750
How Economics Pricing Works
Hypotheses receive an efficiency score (0-1) based on how many knowledge graph edges and citations they produce per token of compute spent.
High-efficiency hypotheses (score >= 0.8) get a price premium in the market, pulling their price toward $0.580.
Low-efficiency hypotheses (score < 0.6) receive a discount, pulling their price toward $0.420.
Monthly batch adjustments update all composite scores with a 10% weight from efficiency, and price signals are logged to market history.
Efficiency Price Signals
| Date | Signal Price | Score |
|---|---|---|
| 2026-04-16T20:00 | $0.480 | 0.510 |
Wiki Pages
ANG ProteinproteinANG — AngiogeningeneParaneoplastic Cerebellar Degeneration NeuronscellC4B GenegeneNeurodegenerationdiseaseC4B ProteinproteinC4B GenegeneAlibaba Tongyi Qianwen-Bio (Chinese Biomedical LLMai_toolASC (PYCARD)geneStrokediseasePyramidal NeuronscellCa1 Pyramidal Neuronscell_typeAlzheimer's DiseasediseaseSchizophreniadiseaseComplement Systementity
KG Entities (2)
Related Hypotheses
TREM2-Dependent Astrocyte-Microglia Cross-talk in Neuroinflammation
Score: 0.000 | neurodegeneration
Focused Ultrasound-Enhanced CYP46A1 Gene Therapy for Neurodegeneration
Score: 0.000 | neurodegeneration
CYP46A1 Inhibition Therapy for Neurodegeneration
Score: 0.000 | neurodegeneration
TREM2-Mediated Senescent Microglial Reprogramming of Astrocyte Networks
Score: 0.000 | neurodegeneration
TREM2-Mediated Oligodendrocyte Metabolic Support in White Matter Neurodegeneration
Score: 0.000 | neurodegeneration
Estimated Development
Estimated Cost
$0
Timeline
2.0 years
🧪 Falsifiable Predictions (4)
4 total
0 confirmed
0 falsified
If hypothesis is true, intervention preserve complement's protective functions in pathogen defense and debris clearance
pending
conf: 0.70
Expected outcome: preserve complement's protective functions in pathogen defense and debris clearance
Falsified by: Intervention fails to preserve complement's protective functions in pathogen defense and debris clearance
If hypothesis is true, intervention benefit most from complement-targeted therapy
pending
conf: 0.70
Expected outcome: benefit most from complement-targeted therapy
Falsified by: Intervention fails to benefit most from complement-targeted therapy
If hypothesis is true, intervention prevent C4b generation
pending
conf: 0.70
Expected outcome: prevent C4b generation
Falsified by: Intervention fails to prevent C4b generation
If hypothesis is true, intervention overcome this limitation
pending
conf: 0.70
Expected outcome: overcome this limitation
Falsified by: Intervention fails to overcome this limitation
Knowledge Subgraph (1 edges)
implicates in (1)
3D Protein Structure
🧬 ... — Search for structure Click to search RCSB PDB
🔍 Searching RCSB PDB for ... structures...
Querying Protein Data Bank API
Source Analysis
Gene expression changes in aging mouse brain predicting neurodegenerative vulnerability
neurodegeneration | 2026-04-02 | completed
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