| Gene Symbol | C4B |
| Full Name | Complement Component 4B (Chido/Rodgers Blood Group) |
| Aliases | Complement component C4B gene |
| Chromosome | 6p21.3 |
| Target Class | Protein |
| Function | encodes a crucial protein in the complement cascade, sharing significant sequence similarity with its close relative C4A while exhibiting distinct biochemical properties and disease associations. |
| Mechanism of Action | Prioritized from 1 SciDEX hypotheses, including: Age-Dependent Complement C4b Upregulation Drives Synaptic Vulnerability in Hippocampal CA1 Neurons |
| Subcellular Localization | </strong></td><td>Secreted (plasma), membrane-bound</td></tr> |
| Druggability | Undruggable (0.23) |
| Molecular Weight | 104 kDa |
| Amino Acids | 1741 aa |
| Pathways | Complement |
| UniProt ID | P0C0S0 |
| NCBI Gene ID | 713 |
| Ensembl ID | ENSG00000244731 |
| OMIM | 120820 |
| GeneCards | C4B |
| Human Protein Atlas | C4B |
| Associated Diseases | Aging, Als, Alzheimer, neurodegeneration |
| Interactions | AND, AXON, C1Q, C1QA, C3, C4 |
| SciDEX Target | View Target Profile |
| KG Connections | 191 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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