gene

AMYLOID-Β PLAQUES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMYLOID-Β PLAQUES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

255Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

AMYLOID-Β PLAQUES is a gene implicated in neurodegeneration research. Key relationships include: inhibits, expressed in, implicated in. Associated with ALS, Aging, Als. Connected to 179 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	AMYLOID
Full Name	Β PLAQUES
GeneCards	AMYLOID
Human Protein Atlas	AMYLOID
Associated Diseases	Aging, Als, Alzheimer, Alzheimer Disease, ALZHEIMER'S DISEASE
Known Drugs/Compounds	DONANEMAB, LECANEMAB, MELATONIN, NICOTINAMIDE, RAPAMYCIN, SEMAGLUTIDE
Interactions	A2M, ABCA1, ABCA7, ABI3, ACE, ACETYLCHOLINE
KG Connections	4765 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    AMYLOID___PLAQUES["AMYLOID-Beta PLAQUES"] -->|"expressed in"| Alzheimer["Alzheimer"]
    AMYLOID___PLAQUES["AMYLOID-Beta PLAQUES"] -->|"expressed in"| Neurodegeneration["Neurodegeneration"]
    AMYLOID___PLAQUES["AMYLOID-Beta PLAQUES"] -.->|"inhibits"| Alzheimer_1["Alzheimer"]
    AMYLOID___PLAQUES["AMYLOID-Beta PLAQUES"] -.->|"inhibits"| Als["Als"]
    AMYLOID___PLAQUES["AMYLOID-Beta PLAQUES"] -.->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    AMYLOID___PLAQUES["AMYLOID-Beta PLAQUES"] -.->|"inhibits"| Neurodegeneration_2["Neurodegeneration"]
    APOE4["APOE4"] -->|"associated"| AMYLOID___PLAQUES["AMYLOID-Beta PLAQUES"]
    MICROGLIA["MICROGLIA"] -->|"therapeutic target"| AMYLOID___PLAQUES["AMYLOID-Beta PLAQUES"]
    TREM2["TREM2"] -->|"expressed in"| AMYLOID___PLAQUES["AMYLOID-Beta PLAQUES"]
    NEURODEGENERATION["NEURODEGENERATION"] -->|"expressed in"| AMYLOID___PLAQUES["AMYLOID-Beta PLAQUES"]
    style AMYLOID___PLAQUES fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (154)

Target	Relation	Type	Str
Alzheimer'S Disease	biomarker_for	disease	0.95
microglia activation	drives	process	0.85
astrocyte activation	drives	process	0.80
Alzheimer	associated_with	disease	0.75
Alzheimer	activates	disease	0.75
Neuroinflammation	associated_with	disease	0.75
Inflammation	associated_with	disease	0.75
Als	inhibits	disease	0.75
Als	associated_with	disease	0.75
Alzheimer	causes	disease	0.75
Dementia	causes	disease	0.75
Alzheimer	expressed_in	disease	0.75
Neurodegeneration	expressed_in	disease	0.75
DEMENTIA	causes	gene	0.70
Mtor	inhibits	pathway	0.70
Pi3K/Akt	inhibits	pathway	0.70
Wnt	inhibits	pathway	0.70
MTOR	inhibits	gene	0.70
NEUROINFLAMMATION	associated_with	gene	0.70
MICROGLIA	activates	gene	0.70
ASTROCYTES	inhibits	gene	0.70
AMYLOID	associated_with	gene	0.70
Alzheimer's disease	associated_with	disease	0.70
Alzheimer	phosphorylates	disease	0.65
ALS	expressed_in	disease	0.65
Tauopathy	expressed_in	disease	0.65
Alzheimer	inhibits	disease	0.65
Aging	expressed_in	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
ALS	associated_with	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Stroke	implicated_in	disease	0.65
ALS	stabilizes	disease	0.65
Alzheimer	stabilizes	disease	0.65
Neurodegeneration	causes	disease	0.65
ALS	causes	disease	0.65
Als	expressed_in	disease	0.65
Traumatic Brain Injury	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Traumatic Brain Injury	implicated_in	disease	0.65
Ms	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	regulates	disease	0.65
Neuroinflammation	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Traumatic Brain Injury	contributes_to	disease	0.65
Parkinson	contributes_to	disease	0.65
Neurodegeneration	contributes_to	disease	0.65

Incoming (101)

Source	Relation	Type	Str
APOE4	associated_with	gene	0.90
APOE4	interacts_with	protein	0.85
ADGRG1	targets	receptor	0.80
TAU	causes	gene	0.80
AMYLOID	causes	gene	0.70
ALZHEIMER'S DISEASE	causes	gene	0.70
OLIGODENDROCYTE	inhibits	gene	0.70
MICROGLIA	inhibits	gene	0.70
AMYLOID	associated_with	gene	0.70
NFKB	inhibits	gene	0.70
PI3K	inhibits	gene	0.70
NEURODEGENERATION	expressed_in	gene	0.70
apoE4	activates	protein	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70
TAU	associated_with	gene	0.70
ALZHEIMER	activates	gene	0.70
ALZHEIMER'S DISEASE	activates	gene	0.70
MICROGLIA	activates	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AMYLOID	phosphorylates	gene	0.60
ASTROCYTES	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
TAU	interacts_with	gene	0.60
TAU TANGLES	interacts_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
ALZHEIMER'S DISEASE	phosphorylates	gene	0.60
TAUOPATHY	expressed_in	gene	0.60
TAU	phosphorylates	gene	0.60
NEUROINFLAMMATION	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
AGING	expressed_in	gene	0.60
ALZHEIMER	phosphorylates	gene	0.60
PRESENILIN	expressed_in	gene	0.60
GSK3	expressed_in	gene	0.60
NEURODEGENERATIVE DISORDERS	expressed_in	gene	0.60
ALZHEIMER	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
APOE4	interacts_with	gene	0.60
NEURODEGENERATIVE DISORDERS	contributes_to	gene	0.60
ASTROCYTES	contributes_to	gene	0.60
PARKINSON'S DISEASE	contributes_to	gene	0.60
CYTOKINES	contributes_to	gene	0.60
PARKINSON	contributes_to	gene	0.60
NEURODEGENERATION	contributes_to	gene	0.60
BRAIN INJURY	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AMYLOID-Β PLAQUES in their description or question text

No additional research found