gene 1,969 words KG: CHUK
Contents

CHUK — IKK Alpha (IκB Kinase Alpha)

🧬 Gene Info
Gene SymbolCHUK
Full NameIKK Alpha (IκB Kinase Alpha)
Chromosome10q24.31
Protein TypeKinase
Functionis a critical serine/threonine protein kinase that plays a central role in the NF-κB signaling pathway.
Molecular Weight85 kDa
Amino Acids745 aa
Exons21
PathwaysNF-κB signaling
UniProt ID[O15111](https://www.uniprot.org/uniprot/O15111)
Ensembl IDENSG00000028137
OMIM600655
GeneCardsCHUK
Human Protein AtlasCHUK
Histone H3At Ser10, linking NF-κB to chromatin remodeling
Associated Diseasesneurodegeneration
InteractionsAND, AUTOPHAGY, BECN1, CANCER, DSDNA, ECSIT
KG Connections94 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (13)

TREM2-Dependent Microglial Senescence Transition
Score: 0.95
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
APOE-Dependent Autophagy Restoration
Score: 0.85
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

See Also (11)

IL6 (Redirect)
redirect · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
AKT1 Gene
gene · KG edge: therapeutic_target
BECN1 Gene
gene · KG edge: activates
ECSIT — Evolutionarily Conserved Signaling Intermediate
gene · KG edge: activates

Knowledge Graph (12 edges)

CHUK inhibits MPXV
CHUK inhibits GAIN
CHUK inhibits MTOR
CHUK inhibits IKBKB
IKBKB inhibits CHUK
GAIN inhibits CHUK
MTOR inhibits CHUK
P38 activates CHUK
IL1B activates CHUK
PRDX1 activates CHUK

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