gene 1,422 words KG: BRAF
Contents

BRAF — B-Raf Proto-Oncogene, Serine/Threonine Kinase

🧬 Gene Info
Gene SymbolBRAF
Full NameB-Raf Proto-Oncogene, Serine/Threonine Kinase
AliasesRAF kinase in MAPK signaling
Protein FamilyRAF serine/threonine kinases
Protein TypeSerine/Threonine Kinase
FunctionBRAF is a serine/threonine-protein kinase that serves as a key intermediate in the RAS-RAF-MEK-ERK signaling cascade.
Molecular Weight84.5 kDa
Amino Acids766 aa
PathwaysMAPK, mapk
UniProt ID[P15056](https://www.uniprot.org/uniprot/P15056)
GeneCardsBRAF
Human Protein AtlasBRAF
Associated DiseasesAD, Als, Ameloblastoma, cancer
Known Drugs/Compoundsdabrafenib, encorafenib + cetuximab, SORAFENIB, TRAMETINIB
InteractionsABCB1, AGING, AKT, AKT3, ALZHEIMER, AMYLOID
KG Connections589 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (30)

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ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
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Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
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Chromatin Accessibility Restoration via BRD4 Modulation
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Senescent Cell Mitochondrial DNA Release
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Near-infrared light therapy stimulates COX4-dependent mitoch
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Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
Autophagosome Maturation Checkpoint Control
Score: 0.71
Extracellular Matrix Stiffness Modulation
Score: 0.69
Hypocretin-Neurogenesis Coupling Therapy
Score: 0.69
Flotillin-1 Stabilization Compounds
Score: 0.68
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
Glial Glycocalyx Remodeling Therapy
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Multi-Modal CRISPR Platform for Simultaneous Editing and Mon
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Related Analyses (21)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (14)

Apoptosis in Neurodegeneration
entity · KG edge: contributes_to
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibits
Astrocytes
entity · KG edge: co_discussed
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: co_discussed
ACVR2A Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

BRAF associated_with PILOCYTIC_ASTROCYTOMA
BRAF associated_with AMELOBLASTOMA
IDH1 associated_with BRAF
TERT associated_with BRAF
JUN biomarker_for BRAF
CIC associated_with BRAF
FUBP1 associated_with BRAF
H3F3A associated_with BRAF
OVERVIEW biomarker_for BRAF
BRAF associated_with ATRX

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