| Gene Symbol | CBL |
| Full Name | Casitas B-lineage Lymphoma |
| Chromosome | 11q23.3 |
| Protein Type | Ligase |
| Function | encodes a RING-type E3 ubiquitin ligase that serves as a critical negative regulator of receptor tyrosine kinase (RTK) signaling. |
| Molecular Weight | 100 kDa |
| Amino Acids | 906 aa |
| Pathways | Inflammasome |
| UniProt ID | [P22681](https://www.uniprot.org/uniprot/P22681) |
| Ensembl ID | ENSG00000110395 |
| GeneCards | CBL |
| Human Protein Atlas | CBL |
| Linker Region | Connects TKB and RING domains, regulatory function |
| C-terminal Proline-Rich Region | Mediates protein-protein interactions with SH3 domain-containing proteins |
| UEV Domain | Ubiquitin-conjugating enzyme variant, substrate recognition |
| Associated Diseases | Als, Alzheimer, Infection, Inflammation, Lymphoma |
| Interactions | ACVR1, AKT, APOPTOSIS, ASC, BAX, BRAIN INJURY |
| KG Connections | 157 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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