concept

LUTEOLIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LUTEOLIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

68Connections

0Hypotheses

0Analyses

50Outgoing

16Incoming

0Experiments

0Debates

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💡 Concept Info

Name	LUTEOLIN
Key Genes/Proteins	AKT, MMP9
Related Diseases	ANGIOGENESIS, APOPTOSIS, ATHEROSCLEROSIS, BREAST CANCER, CANCER
Related Pathways	AKT_MTOR_PATHWAY

Pathway Diagram

graph TD
    LUTEOLIN["LUTEOLIN"]
    LUTEOLIN -->|"inhibits"| Triple_Negative_Breast_Cancer["Triple-Negative Breast Cancer"]
    LUTEOLIN -->|"inhibits"| Cell_Proliferation["Cell Proliferation"]
    LUTEOLIN -->|"inhibits"| Cell_Metastasis["Cell Metastasis"]
    LUTEOLIN -->|"downregulates"| MMP9["MMP9"]
    LUTEOLIN -->|"activates"| PI3K_AKT_axis["PI3K/AKT axis"]
    LUTEOLIN -->|"treats"| postmenopausal_osteoporosis["postmenopausal osteoporosis"]
    LUTEOLIN -->|"inhibits"| Akt_Mtor["Akt/Mtor"]
    LUTEOLIN -->|"activates"| PI3K_AKT["PI3K/AKT"]

Outgoing (52)

Target	Relation	Type	Str
PI3K/AKT axis	activates	pathway	0.95
Cell Proliferation	inhibits	process	0.95
Cell Metastasis	inhibits	process	0.95
Triple-Negative Breast Cancer	inhibits	disease	0.95
MMP9	downregulates	gene	0.95
Inflammation	inhibits	process	0.95
Apoptosis	inhibits	process	0.95
Ferroptosis	inhibits	process	0.95
postmenopausal osteoporosis	treats	disease	0.93
Akt/Mtor	inhibits	pathway	0.90
AKT/MTOR Signaling Pathway	associated_with	pathway	0.90
ALOX12	targets	gene	0.90
PI3K/AKT	activates	pathway	0.90
PI3K	modulates	protein	0.85
ALOX12	downregulates	gene	0.85
Senescent Cells	targets	cell_type	0.85
Epithelial-Mesenchymal Transition	inhibits	process	0.85
NAT10	inhibits	gene	0.85
mitochondrial function	restores	process	0.85
MTOR Inhibitors	interacts_with	drug	0.80
AKT Inhibitors	interacts_with	drug	0.80
angiogenesis	promotes	process	0.80
ferroptosis	inhibits	process	0.80
cell proliferation	promotes	process	0.80
apoptosis	inhibits	process	0.80
inflammation	inhibits	process	0.80
Atherosclerosis	treats	disease	0.75
Insomnia	associated_with	disease	0.75
ANDROGEN RECEPTOR	targets	receptor	0.75
AKT_MTOR_PATHWAY	inhibits	pathway	0.72
MMP9	regulates	protein	0.72
MMP9	interacts_with	protein	0.70
INFLAMMATION	treats	phenotype	0.70
INFLAMMATION	activates	phenotype	0.70
MAPK Signaling Pathway	modulates	pathway	0.70
OSTEOPOROSIS	treats	disease	0.65
METASTASIS	inhibits	phenotype	0.65
AKT	activates	gene	0.65
AKT	inhibits	gene	0.65
MMP9	inhibits	gene	0.65
BREAST CANCER	inhibits	disease	0.65
TNF	modulates	protein	0.65
ATHEROSCLEROSIS	inhibits	disease	0.65
CELL PROLIFERATION	activates	phenotype	0.65
TNBC	treats	disease	0.64
EMT	inhibits	phenotype	0.64
NRF2	associated_with	gene	0.45
CANCER	associated_with	disease	0.45
MTOR	associated_with	gene	0.45
MMP9	associated_with	gene	0.45

Incoming (16)

Source	Relation	Type	Str
CHOLESTEROL	inhibits	phenotype	0.65
NEURODEGENERATIVE DISORDERS	modulates	gene	0.60
ATHEROSCLEROSIS	associated_with	disease	0.50
ANGIOGENESIS	associated_with	phenotype	0.50
INFLAMMATION	associated_with	phenotype	0.50
FERROPTOSIS	associated_with	phenotype	0.50
APOPTOSIS	associated_with	phenotype	0.50
REMYELINATION	associated_with	phenotype	0.45
CHOLESTEROL	associated_with	phenotype	0.45
MTOR SIGNALING	associated_with	pathway	0.45
BREAST CANCER	associated_with	disease	0.45
OSTEOPOROSIS	associated_with	disease	0.45
EPITHELIAL-MESENCHYMAL TRANSITION	associated_with	phenotype	0.45
METASTASIS	associated_with	phenotype	0.45
PYROPTOSIS	associated_with	phenotype	0.45
CELL PROLIFERATION	associated_with	phenotype	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LUTEOLIN in their description or question text

No additional research found