concept

IRF8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRF8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

76Connections

0Hypotheses

0Analyses

50Outgoing

22Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	IRF8
Key Genes/Proteins	AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, ASTROCYTE
Related Diseases	Als, ALS, Alzheimer, Atherosclerosis
Related Pathways	Apoptosis, apoptosis pathway

Pathway Diagram

graph TD
    IRF8["IRF8"]
    IRF8 -->|"activates"| Atherosclerosis["Atherosclerosis"]
    IRF8 -->|"activates"| Lymphoma["Lymphoma"]
    IRF8 -->|"regulates"| Als["Als"]
    IRF8 -->|"regulates"| ALS["ALS"]
    IRF8 -->|"regulates"| microglia["microglia"]
    IRF8 -->|"regulates"| IFNG["IFNG"]
    IRF8 -->|"causes"| MICROGLIA["MICROGLIA"]
    IRF8 -->|"activates"| APOPTOSIS["APOPTOSIS"]
    S1PR1["S1PR1"] -->|"upregulates"| IRF8
    S1P1["S1P1"] -->|"upregulates"| IRF8
    IL_10["IL-10"] -->|"activates"| IRF8
    AKT["AKT"] -->|"activates"| IRF8
    LDL["LDL"] -->|"activates"| IRF8
    MAF["MAF"] -->|"activates"| IRF8
    ATP["ATP"] -->|"activates"| IRF8
    MAPK["MAPK"] -->|"activates"| IRF8

Outgoing (54)

Target	Relation	Type	Str
Reactive Microglia	regulates	phenotype	0.80
microglia	expressed_in	cell_type	0.70
Encephalitis	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
ALS	regulates	disease	0.65
Als	regulates	disease	0.65
Lymphoma	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
MAF	activates	gene	0.60
MTOR	activates	gene	0.60
B Cell	activates	cell_type	0.60
Interferon	activates	protein	0.60
C4B	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
MICROGLIA	causes	gene	0.60
Myelination	associated_with	pathway	0.60
OLIGODENDROCYTE	associated_with	gene	0.60
ASTROCYTE	associated_with	gene	0.60
RNA	associated_with	gene	0.60
AND	associated_with	gene	0.60
AND	activates	gene	0.60
Apoptosis	activates	pathway	0.60
Sphingolipid	activates	pathway	0.60
Mtor	activates	pathway	0.60
IFN	regulates	gene	0.60
RNA	regulates	gene	0.60
Microglia	regulates	cell_type	0.60
IFN-Γ	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
MERTK	activates	gene	0.60
Mapk	activates	pathway	0.60
Il-1	activates	protein	0.60
LXR	activates	gene	0.60
PKA	activates	gene	0.60
microglia	regulates	cell_type	0.60
IFNG	regulates	gene	0.60
AKT	activates	gene	0.60
MAPK	activates	gene	0.60
LDL	activates	gene	0.60
IL-10	activates	gene	0.60
Cholesterol	activates	pathway	0.60
Macrophage	activates	cell_type	0.60
apoptosis pathway	participates_in	pathway	0.60
macrophages	expressed_in	cell_type	0.60
MAPK signaling	participates_in	pathway	0.60
neuroinflammation	activates	disease	0.60
Interferon	regulates	protein	0.60
Oligodendrocyte	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55
T Cell	expressed_in	cell_type	0.55

Incoming (22)

Source	Relation	Type	Str
S1P1	upregulates	receptor	0.85
ASTROCYTE	associated_with	gene	0.60
OLIGODENDROCYTE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	associated_with	gene	0.60
RNA	associated_with	gene	0.60
JUN	associated_with	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
IL-10	activates	gene	0.60
AKT	activates	gene	0.60
LDL	activates	gene	0.60
MAF	activates	gene	0.60
ATP	activates	gene	0.60
MAPK	activates	gene	0.60
AND	activates	gene	0.60
MTOR	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
RNA	regulates	gene	0.60
AND	regulates	gene	0.60
IFN	regulates	gene	0.60
MERTK	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IRF8 in their description or question text

No additional research found