concept

HER2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HER2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

327Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	HER2
Key Genes/Proteins	AGER, AKT, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Akt, Amyloid, Angiogenesis

Pathway Diagram

graph TD
    HER2["HER2"]
    style HER2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    HER2 -->|"regulates"| Cell_Proliferation["Cell Proliferation"]
    HER2 -->|"regulates"| Cell_Survival["Cell Survival"]
    HER2 -->|"promotes"| cell_proliferation["cell proliferation"]
    HER2 -->|"promotes"| cell_survival["cell survival"]
    HER2 -.->|"biomarker for"| Breast_Cancer["Breast Cancer"]
    HER2 -->|"activates"| AKT([AKT])
    HER2 -->|"activates"| PI3K([PI3K])
    HER2 -->|"regulates"| cell_differentiation["cell differentiation"]
    HER2 -->|"target for"| cancer["cancer"]
    n_5A["5A"] -.->|"inhibits"| HER2
    trastuzumab{"trastuzumab"} -->|"target for"| HER2
    pertuzumab{"pertuzumab"} -->|"target for"| HER2
    EGFR([EGFR]) -->|"interacts"| HER2
    PI3K -.->|"inhibits"| HER2
    CANCER([CANCER]) -->|"target for"| HER2
    CDK4([CDK4]) -->|"target for"| HER2
    MTOR([MTOR]) -.->|"inhibits"| HER2
    AND([AND]) -->|"target for"| HER2
    AKT -.->|"inhibits"| HER2

Outgoing (190)

Target	Relation	Type	Str
Gastric Cancer	associated_with	disease	0.98
Breast Cancer	associated_with	disease	0.98
Cell Proliferation	regulates	process	0.95
Cell Survival	regulates	process	0.95
cell proliferation	promotes	process	0.95
cell survival	promotes	process	0.95
cell differentiation	regulates	process	0.90
PI3K	activates	protein	0.90
cancer	targets	disease	0.90
AKT	activates	protein	0.90
EGFR Family	interacts_with	protein	0.88
ERK	upstream_of	protein	0.85
oxidative stress response	participates_in	pathway	0.80
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
Ms	causes	disease	0.65
Cancer	associated_with	disease	0.65
Aging	causes	disease	0.65
Alzheimer	causes	disease	0.65
Tumor	causes	disease	0.65
Als	causes	disease	0.65
Cancer	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Als	associated_with	disease	0.65
Tumor	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
ALS	causes	disease	0.65
Tumor	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	expressed_in	disease	0.65
Cancer	regulates	disease	0.65
Tumor	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
Als	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Tumor	inhibits	disease	0.65
Aging	inhibits	disease	0.65
ALS	activates	disease	0.65
Inflammation	activates	disease	0.65
Cancer	inhibits	disease	0.65
Als	activates	disease	0.65
ALS	inhibits	disease	0.65
Ras	therapeutic_target	protein	0.60
Rb	associated_with	protein	0.60

Incoming (137)

Source	Relation	Type	Str
trastuzumab	therapeutic_target	drug	0.90
pertuzumab	therapeutic_target	drug	0.90
EGFR	interacts_with	gene	0.80
HSP90	inhibits	gene	0.60
EIF2A	inhibits	gene	0.60
ERBB2	biomarker_for	gene	0.60
EGFR	inhibits	gene	0.60
ERBB2	interacts_with	gene	0.60
DLL4	implicated_in	gene	0.60
ERBB3	activates	gene	0.60
PER	activates	gene	0.60
TFE3	activates	gene	0.60
GAS6	associated_with	gene	0.60
AXL	associated_with	gene	0.60
ASTROCYTES	associated_with	gene	0.60
PI3K	inhibits	gene	0.60
CANCER	therapeutic_target	gene	0.60
CDK4	therapeutic_target	gene	0.60
MTOR	inhibits	gene	0.60
AKT	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
SOD1	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
ERK	inhibits	gene	0.60
C-JUN	inhibits	gene	0.60
MEK	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
JUN	inhibits	gene	0.60
FOXO	inhibits	gene	0.60
TFEB	activates	gene	0.60
BAD	inhibits	gene	0.60
ERBB2	inhibits	gene	0.60
PER	associated_with	gene	0.60
ERBB2	targets	gene	0.60
AKT	associated_with	gene	0.60
ERK	activates	gene	0.60
EGFR	associated_with	gene	0.60
MTOR	activates	gene	0.60
PI3K	activates	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
MITOPHAGY	associated_with	gene	0.60
CD8	activates	gene	0.60
GENES	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
CGAS	activates	gene	0.60
PD-L1	activates	gene	0.60
DR5	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HER2 in their description or question text

No additional research found