gene 582 words KG: MMP3
Contents

MMP3 Gene

🧬 Gene Info
Gene SymbolMMP3
Chromosome11q22.3.
FunctionMMP3 encodes matrix metalloproteinase 3 (MMP-3), also known as stromelysin-1, a member of the zinc-dependent metalloproteinase family.
PathwaysFerroptosis, Synaptic Plasticity, Long-Term Potentiation, Oxidative Stress, Apoptosis
Ensembl IDENSG00000149968
GeneCardsMMP3
Human Protein AtlasMMP3
Associated DiseasesAtherosclerosis, Inflammation, Stroke
Known Drugs/Compoundsicariin
InteractionsCCL20, CHI3L1, Collagen, CXCL8, FER, FERROPTOSIS
KG Connections136 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (12)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
Piezoelectric Nanochannel BBB Disruption
Score: 0.52

Related Analyses (7)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (15)

Astrocytes
entity · KG edge: expressed_in
Ferroptosis Validation in Parkinson's Disease
experiment · KG edge: activates
Genes
index · KG edge: associated_with
CCL20 Gene
gene · KG edge: associated_with
CHI3L1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

icariin inhibits MMP3
MMP3 activates GPX4
MMP3 activates SOX9
MMP3 activates SLC7A11
MMP3 activates MMP1
MMP3 activates FER
MMP9 inhibits MMP3
SST inhibits MMP3
GPX4 activates MMP3
SLC7A11 activates MMP3

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.