| Gene Symbol | MMP1 |
| Full Name | Matrix Metalloproteinase 1 |
| Aliases | Page for MMP1 |
| Protein Type | Enzyme |
| Function | MMP1 (Matrix Metallopeptidase 1), also known as interstitial collagenase, is a zinc-dependent endopeptidase that degrades native collagen types I, II, and III. |
| Pathways | TGF-β |
| Ensembl ID | ENSG00000196611 |
| GeneCards | MMP1 |
| Human Protein Atlas | MMP1 |
| Extracellular Matrix Degradation | MMP1 cleaves collagen I, II, III, gelatin, and other matrix proteins. This activity is essential for tissue remodeling during development, wound healing, and injury response. |
| Inflammatory Signaling | MMP1 releases bioactive fragments from matrix proteins that act as chemotactic signals for immune cells. It activates pro-inflammatory cytokines and modulates immune responses. |
| Amyloid Processing | MMP1 can degrade Aβ peptides and may contribute to amyloid clearance in the brain. However, dysregulated MMP1 activity can also generate toxic fragments. |
| Growth Factor Activation | MMP1 releases and activates growth factors from the extracellular matrix, including TGF-β, influencing cell proliferation and differentiation. |
| Associated Diseases | ALS, Cancer, Fibrosis, neuroinflammation, oxidative stress, Senescence |
| Known Drugs/Compounds | icariin |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, APOE, App, ASTROCYTE, ASTROCYTES |
| KG Connections | 229 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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