Contents

ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Member 4

🧬 Gene Info

Gene Symbol	ACSL4
Full Name	Acyl-CoA Synthetase Long Chain Family Member 4
Chromosome	Xq22.3
Protein Type	Synthetase
Target Class	Enzyme
Function	is an important component in the neurobiology of neurodegenerative diseases.
Mechanism of Action	Enzyme inhibition — blocking ACSL4 prevents incorporation of PUFAs into membrane phospholipids, reducing ferroptosis susceptibility
Primary Expression	various neural cell types:
Druggability	Low (0.41)
Clinical Stage	Phase III
Pathways	Autophagy, Cholesterol, Epigenetic, Ferroptosis, Inflammasome
UniProt ID	[O60488](https://www.uniprot.org/uniprot/O60488)
Ensembl ID	ENSG00000068366
GeneCards	ACSL4
Human Protein Atlas	ACSL4
Associated Diseases	ALS, alzheimer_s_disease, Alzheimer's Disease, CANCER, Carcinoma, Fibrosis
Known Drugs/Compounds	Calycosin, curcumin, CURCUMIN, metformin, METFORMIN, PIOGLITAZONE
Interactions	AKT, ALOX12, ALOX15, ALOX5, ALZHEIMER, ALZHEIMER'S DISEASE
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	ACSL4-Driven Ferroptotic Priming in Disease-Associ 40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferro ACSL4-Ferroptotic Priming in Stressed Oligodendroc (+1 more)
KG Connections	746 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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