Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about C4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | C4 |
| Key Genes/Proteins | APP, C1Q, C1QA, C3, C4A, C4B |
| Related Pathways | complement cascade, insulin signaling |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
C4[C4]
C4 -->|mediates| Synapse_Elimination[Synapse Elimination]
C4 -->|participates in| complement_cascade[complement cascade]
C4 -->|expressed in| microglia[microglia]
C4 -->|interacts| C4A[C4A]
C4 -->|interacts| C4B[C4B]
C4 -->|interacts| schizophrenia[schizophrenia]
C4 -->|expressed in| neurons[neurons]
C4 -->|expressed in| oligodendrocytes[oligodendrocytes]
C4 -->|participates in| insulin_signaling[insulin signaling]
C4 -->|activates| STAT1[STAT1]
C3[C3] -->|interacts| C4
benchmark_ot_ad_answer_key_C4[benchmark_ot_ad_answer_key:C4] -->|data_in| C4| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:C4 | data_in | dataset_row | 0.00 |
| Synapse Elimination | mediates | process | 0.91 |
| Neuronal Synapses | associated_with | structure | 0.88 |
| complement cascade | participates_in | pathway | 0.85 |
| microglia | expressed_in | cell_type | 0.75 |
| neurons | expressed_in | cell_type | 0.60 |
| C4B | interacts_with | gene | 0.60 |
| oligodendrocytes | expressed_in | cell_type | 0.60 |
| schizophrenia | interacts_with | disease | 0.60 |
| C4A | interacts_with | gene | 0.60 |
| STAT1 | activates | gene | 0.55 |
| senescence | participates_in | pathway | 0.55 |
| astrocytes | expressed_in | cell_type | 0.55 |
| IFN | activates | gene | 0.55 |
| JAK | activates | gene | 0.55 |
| JAK-STAT signaling | participates_in | pathway | 0.55 |
| unfolded protein response | participates_in | pathway | 0.55 |
| insulin signaling | participates_in | pathway | 0.55 |
| CR1 | co_discussed | gene | 0.40 |
| CLU | co_discussed | gene | 0.40 |
| TNF | co_discussed | gene | 0.40 |
| NLRP3 | co_discussed | gene | 0.40 |
| GFAP | co_discussed | gene | 0.40 |
| TAU | co_discussed | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| GPC4/HSPGs Collaborate with ApoE Isoforms to Dictate Tau Con | 0.583 | neurodegeneration | What are the specific molecular determin |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-12 | 2 hypotheses Top: 0.682
neurodegeneration | 2026-04-04 | 5 hypotheses Top: 0.640
neurodegeneration | 2026-04-02 | 5 hypotheses Top: 0.761
neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.910
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.70 · 2026-04-12
closed · Rounds: 4 · Score: 0.89 · 2026-04-06
closed · Rounds: 4 · Score: 0.88 · 2026-04-04
closed · Rounds: 3 · Score: 0.68 · 2026-04-02
Hypotheses and analyses mentioning C4 in their description or question text
No additional research found