| Gene Symbol | FERROPORTIN |
| Chromosome | 2q32.2 |
| Function | Ferroportin serves as the cellular iron export channel |
| Subcellular Localization | Plasma membrane, Endosomes |
| Molecular Weight | 70 kDa |
| Amino Acids | 571 aa |
| Pathways | Alpha-Synuclein, Ferroptosis |
| UniProt ID | [Q9NP59](https://www.uniprot.org/uniprot/Q9NP59) |
| GeneCards | FERROPORTIN |
| Human Protein Atlas | FERROPORTIN |
| 12-16 transmembrane helices | Exact topology debated; recent cryo-EM structures show 12 TMs |
| N-terminal cytoplasmic domain | Contains regulatory phosphorylation sites |
| Hephaestin/ceruloplasmin binding site | Enables Fe²⁺ oxidation upon export |
| Hepcidin binding site | Extracellular loop between TM5 and TM6 |
| Enterocytes | DMT1 imports → ferroportin exports dietary iron |
| Associated Diseases | neurodegeneration |
| Interactions | AND, DJ-1, HEPCIDIN, TRANSFERRIN |
| KG Connections | 80 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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