| Gene Symbol | SLC40A1 |
| Aliases | ferroportin |
| Function | SLC40A1 encodes ferroportin, the only known iron exporter in mammals. |
| Primary Expression | cells that export iron, including macrophages, hepatocytes, and enterocytes |
| Pathways | Inflammasome, Nf-Κb |
| Ensembl ID | ENSG00000138448 |
| GeneCards | SLC40A1 |
| Human Protein Atlas | SLC40A1 |
| Iron export | Ferroportin exports iron from cells into the plasma |
| Systemic iron regulation | Controls iron entry into circulation from gut, liver, and spleen |
| Hepcidin receptor | Ferroportin is the target of hepcidin, the iron regulatory hormone |
| Cellular iron homeostasis | Prevents iron accumulation in macrophages and other cells |
| Iron overload | Mutations lead to iron accumulation in the brain, particularly in the globus pallidus |
| Motor symptoms | Patients present with progressive dystonia, parkinsonism, and gait disturbance |
| Cognitive decline | Some patients develop cognitive impairment |
| Associated Diseases | ALS, Cancer, iron overload |
| Interactions | ASC, C1QA, CD8, COX2, FERROPTOSIS, GPX4 |
| KG Connections | 85 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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