gene 2,409 words KG: HERC4
Contents

HERC4 (HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 4)

🧬 Gene Info
Gene SymbolHERC4
Full NameHECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 4
Chromosome10q21.3
Protein TypeLigase
Functionis a member of the HERC family of E3 ubiquitin ligases that play critical roles in protein ubiquitination, cellular signaling, and protein quality control.
Molecular Weight53 kDa
Amino Acids475 aa
UniProt IDQ8N7R4
NCBI Gene ID26091
Ensembl IDENSG00000138641
OMIM610215
GeneCardsHERC4
Human Protein AtlasHERC4
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

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Related Hypotheses (15)

Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
APOE-Dependent Autophagy Restoration
Score: 0.86
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
PARP1 Inhibition Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Alpha-Synuclein Seeding Assays (RT-QuIC and PMCA)
biomarker · Pages share 3 hypotheses
IL-6 (Interleukin-6) in Neurodegeneration
biomarker · Pages share 3 hypotheses
Cell-Free DNA Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses
Exosomal Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

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