gene 1,399 words KG: SLC44A2
Contents

SLC44A2 (CTL2)

🧬 Gene Info
Gene SymbolSLC44A2
Full NameSolute Carrier Family 44 Member 2
Chromosome9p21.2
Protein TypeTransporter
Functionencodes a member of the Solute Carrier Family 44.
Primary Expressionvarious tissues including the brain, blood cells, and epithelial tissues
PathwaysTgf-Β
UniProt ID[Q8WWI5](https://www.uniprot.org/uniprot/Q8WWI5)
Ensembl IDENSG00000137767
GeneCardsSLC44A2
Human Protein AtlasSLC44A2
Choline UptakeSLC44A2 mediates cellular uptake of choline, an essential nutrient.
Phosphatidylcholine SynthesisCholine is the precursor for phosphatidylcholine biosynthesis, the most abundant phospholipid in mammalian membranes.
Acetylcholine SynthesisCholine is the precursor for acetylcholine, a key neurotransmitter.
Membrane MaintenanceCholine is required for maintaining membrane integrity and lipid homeostasis.
Associated DiseasesCardiovascular
InteractionsCPT2, MUL1, NRP1, UBIQUITIN
KG Connections13 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (9)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72

Related Analyses (3)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Ubiquitin-Proteasome System Therapeutic Companies for P
company · KG edge: inhibits
Neurodegeneration
disease · KG edge: implicated_in
Tumor Necrosis Factor (TNF)
entity · KG edge: therapeutic_target
ANG — Angiogenin
gene · KG edge: protects_against
CPT2
gene · KG edge: inhibits

Knowledge Graph (12 edges)

ANG protects_against SLC44A2
NRP1 activates SLC44A2
APOE associated_with SLC44A2
UBIQUITIN inhibits SLC44A2
CPT2 inhibits SLC44A2
SLC44A2 inhibits MUL1
SLC44A2 associated_with RUNX1
SLC44A2 associated_with Cardiovascular
SLC44A2 activates Tgf-Β
CANCER expressed_in SLC44A2

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