concept

DISEASE-ASSOCIATED MICROGLIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DISEASE-ASSOCIATED MICROGLIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

358Connections

10Hypotheses

0Analyses

50Outgoing

50Incoming

3Experiments

0Debates

Summary

DISEASE-ASSOCIATED MICROGLIA is a concept in neurodegeneration research. Key relationships include: activates, associated with, expressed in. Associated with Aging, Als, Alzheimer. Connected to 146 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	DISEASE-ASSOCIATED MICROGLIA
Key Genes/Proteins	AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, APOE
Related Diseases	Aging, Als, ALS, Alzheimer, Alzheimer'S Disease
Related Pathways	Amyloid, Angiogenesis, Apoptosis

Wiki Pages (1)

Knowledge base pages for this entity

Disease-Associated Microglia

cell · 1120 words

Pathway Diagram

graph TD
    DISEASE_ASSOCIATED_MICROGLIA["DISEASE-ASSOCIATED MICROGLIA"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"activates"| Ms["Ms"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"activates"| Tumor["Tumor"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"expressed in"| Inflammation["Inflammation"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"expressed in"| Alzheimer["Alzheimer"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"expressed in"| Aging["Aging"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"expressed in"| Tauopathy["Tauopathy"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"expressed in"| Dementia["Dementia"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"target for"| Als["Als"]
    TREM2["TREM2"] -->|"regulates"| DISEASE_ASSOCIATED_MICROGLIA
    MICROGLIA["MICROGLIA"] -->|"activates"| DISEASE_ASSOCIATED_MICROGLIA
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"activates"| DISEASE_ASSOCIATED_MICROGLIA
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| DISEASE_ASSOCIATED_MICROGLIA
    CYTOKINES["CYTOKINES"] -->|"activates"| DISEASE_ASSOCIATED_MICROGLIA
    TNF["TNF"] -->|"activates"| DISEASE_ASSOCIATED_MICROGLIA
    TNFR1["TNFR1"] -->|"activates"| DISEASE_ASSOCIATED_MICROGLIA
    AGING["AGING"] -->|"expressed in"| DISEASE_ASSOCIATED_MICROGLIA
    BCL2["BCL2"] -->|"expressed in"| DISEASE_ASSOCIATED_MICROGLIA

Outgoing (241)

Target	Relation	Type	Str
Alzheimer'S Disease	associated_with	disease	0.95
Neurodegeneration	activates	disease	0.95
Neurodegeneration	associated_with	disease	0.95
Alzheimer's Disease	biomarker_for	disease	0.90
Microglial Subtypes	associated_with	cell_type	0.90
Central Nervous System Damage	mediates	process	0.90
pro-inflammatory factors	upregulates	protein	0.90
TREM2	associated_with	gene	0.90
Amyloid Beta	interacts_with	protein	0.90
Pathological Phenotypes	contributes_to	phenotype	0.90
Multiple Sclerosis	associated_with	disease	0.90
Alzheimer's Disease	associated_with	disease	0.90
Neuroprotective Signature	expressed_in	phenotype	0.90
Central Nervous System Damage	involved_in	process	0.90
Alzheimer'S	involved_in	disease	0.87
Alzheimer's Disease	implicated_in	disease	0.85
Amyloid Pathology	regulates	process	0.85
amyloid-beta	downregulates	compound	0.85
Autism Spectrum Disorder	associated_with	disease	0.85
Alzheimer'S Disease Progression	modulates	process	0.85
Lewy Body Diseases	associated_with	disease	0.85
Brain Protection	protects_against	process	0.85
Neuroinflammation	promotes	process	0.85
Epilepsy	associated_with	disease	0.85
Neurodegeneration	protects_against	disease	0.85
Microglia	associated_with	cell_type	0.85
Early Cns Damage Detection	involved_in	process	0.85
Alzheimer	activates	disease	0.85
Neurodegeneration Therapeutic Target	therapeutic_target	mechanism	0.80
Neurodegeneration	mediates	process	0.80
Neuroinflammation	contributes_to	process	0.80
NEURODEGENERATIVE DISEASES	associated_with	disease	0.80
Neurodegenerative Diseases	therapeutic_target	disease	0.80
MICROGLIA	activates	gene	0.80
MICROGLIA	associated_with	gene	0.80
Aging	associated_with	disease	0.75
Als	associated_with	disease	0.75
Alzheimer	associated_with	disease	0.75
Alzheimer	expressed_in	disease	0.75
Inflammation	activates	disease	0.75
Brain Aging	associated_with	phenotype	0.75
Neuroinflammation	activates	disease	0.75
Als	activates	disease	0.75
Biomarker	biomarker_for	biomarker	0.75
Brain Aging	biomarker_for	disease	0.75
Neurodegeneration	associated_with	disease	0.75
MYELIN	activates	gene	0.70
ALZHEIMER'S DISEASE	expressed_in	gene	0.70
Alzheimer's disease	associated_with	disease	0.70
NEUROINFLAMMATION	activates	gene	0.70

Incoming (117)

Source	Relation	Type	Str
TREM2	involved_in	gene	0.95
Alzheimer'S Disease	associated_with	disease	0.90
TREM2	regulates	protein	0.90
APOE	regulates	gene	0.90
TREM2	regulates	gene	0.90
Alzheimer's Disease	associated_with	disease	0.90
GPNMB	expressed_in	gene	0.90
White Matter-Associated Microglia	co_expressed_with	cell_type	0.88
TREM2 Signaling Pathway	regulates	pathway	0.88
TREM2	expressed_in	gene	0.85
TYROBP	regulates	protein	0.85
White Matter-Associated Microglia	associated_with	cell_type	0.85
Microglia Checkpoint Molecules	downregulates	mechanism	0.85
Alzheimer'S Disease	causes	disease	0.85
TREM2	modulates	protein	0.80
TREM2	activates	gene	0.80
NEURODEGENERATION	activates	gene	0.80
TAU	activates	gene	0.80
AMYLOID	activates	gene	0.70
TAU PATHOLOGY	activates	gene	0.70
ALZHEIMER	activates	gene	0.70
ALZHEIMER	expressed_in	gene	0.70
CYTOKINES	activates	gene	0.70
TREM2	associated_with	gene	0.70
TREM2	regulates	gene	0.70
NEURODEGENERATIVE DISEASES	associated_with	gene	0.70
NEURODEGENERATION	associated_with	gene	0.70
MICROGLIA	targets	cell_type	0.65
BCL2 FAMILY	expressed_in	gene	0.60
CLN3	therapeutic_target	gene	0.60
DMSO	therapeutic_target	gene	0.60
ERK	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
ASTROCYTES	associated_with	gene	0.60
CXCL10	associated_with	gene	0.60
TAU PATHOLOGY	therapeutic_target	gene	0.60
C1QA	associated_with	gene	0.60
TAU	therapeutic_target	gene	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
DRD1	therapeutic_target	gene	0.60
GPNMB	therapeutic_target	gene	0.60
AGING	expressed_in	gene	0.60
CX3CR1	therapeutic_target	gene	0.60
P2RY12	therapeutic_target	gene	0.60
ASTROCYTES	causes	gene	0.60
ERK1/2	activates	gene	0.60
PARKINSON	associated_with	gene	0.60
NLRP3	therapeutic_target	gene	0.60
BCL2	expressed_in	gene	0.60
MICROGLIA	associated_with	gene	0.60

Targeting Hypotheses (10)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro	0.847	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Pri	0.801	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferrop	0.779	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Sub	0.776	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vul	0.770	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di

TREM2 haploinsufficiency dysregulates microglial synaptic su	0.700	neurodegeneration	Synaptic pruning by microglia in neurode
Disease-Associated Microglia Metabolic Reprogramming	0.631	neurodegeneration	Cell type vulnerability in Alzheimers Di
Disease-Associated Microglia (DAM) Program Drives IBA1 Downr	0.571	neuroinflammation	What causes IBA1 low/negative microglia
Closed-loop tFUS targeting of EC-II SST interneurons to prev	0.000	Alzheimer's disease	Circuit-level neural dynamics in neurode
ACSL4-Mediated Neuroinflammatory Amplification in Disease-As	0.000	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
SAHA@LIPO-ANG2 therapeutic efficacy in 5xFAD mice	validation	Alzheimer's disease	0.900	0.00	5xFAD transgenic mice	proposed	N/A
Transcriptomic profiling and differential expression analysis	exploratory	Alzheimer's disease	0.900	0.00	1-month-old APP/PS1 mice cereb	proposed	N/A
bEV isolation and LPS quantification from human samples	clinical	Alzheimer's disease	0.800	0.00	human patients	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655]	Jorstad NL, Close J, Johansen N, Yanny A	Science	2023	186
FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression. [PMID:41862445]	Qin J, Ma S, Wang J, Huang S, Luan J, He	Cell death & disease	2026	0
Quercetin attenuates ox-LDL-induced endothelial injury by regulating ferroptosis [PMID:41902795]	Gao C, Liu B, Zhang R, Tian J, Xin H	Toxicology mechanisms and meth	2026	0
NEDD8 promotes the ferritinophagy and ferroptosis of neurons in ischemic stroke [PMID:41662890]	Rao W, Huang Y, Li J, Chen Q, Sun J et a	J Stroke Cerebrovasc Dis	2026	0
Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892]	Lin D, Li K, Kuang W, Chen Z, Zhang M	World J Mens Health	2026	0
Deciphering sorafenib resistance in hepatocellular carcinoma via ferroptotic mec [PMID:41763496]	Che L, Zhu L, Zhou L, Zhou Y	Biochim Biophys Acta Rev Cance	2026	0
B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis [PMID:41860570]	Chien Y, Xia R, Zhou D, Ai Y, Wu L et al	Hepatol Commun	2026	0
Unraveling the impact of risk factors on the ferroptosis-Alzheimer's disease lin [PMID:41498558]	Singh P, Rath SL	Journal of Alzheimer's disease	2026	0
Resveratrol Alleviates Intervertebral Disc Degeneration by Targeting NCOA4-Media [PMID:41873334]	Song C, Wu X, Chen C, Shen B, He Y, Liu	Drug design, development and t	2026	0
Pan-PPAR agonist bezafibrate alleviates psoriasis by suppressing LCN2-dependent [PMID:41662914]	["Xin R", "Zhang J", "Zhang Y", "Dai M",	Free radical biology & medicin	2026	0
Acteoside alleviates sepsis-induced acute lung injury by activating the Nrf2 pat [PMID:41895086]	Wang Y, Zhang W, Zhang M, Zhu Y, Wang W,	Tissue & cell	2026	0
Ferroptosis and microglial polarization in retinal vein occlusion: pathological [PMID:41924362]	Xu J, Sun M, Wang C, Ju P, Guan XD, Xie	International journal of ophth	2026	0
Melatonin Alleviates Erastin-Induced Cell Death by Inhibiting Ferroptosis and Am [PMID:40442550]	Wongjaikam S, Siengdee P, Somnus A, Govi	Neurotoxicity research	2025	0
Acyl-CoA synthetase long-chain family member 4-A novel prognostic marker in cuta [PMID:41918944]	Paria S, Lapides R, Saravi B, Rajagopal	Frontiers in medicine	2025	0
Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzhei [PMID:40640358]	Zhu L, Zhou T, Wu L, Zhu X, Chen L, Zhan	Scientific reports	2025	0
Microbiota-derived lysophosphatidylcholine alleviates Alzheimer's disease pathol [PMID:39510074]	["Zha Xu", "Liu Xicheng", "Wei Mengping"	Cell metabolism	2025	0
Upregulation of MAM by C99 disrupts ACSL4 activity and phospholipid homeostasis [PMID:41394684]	Montesinos J, Yun TD, Salomón-Cruz ID, A	bioRxiv : the preprint server	2025	0
Danggui Shaoyao San ameliorates Alzheimer's disease by regulating lipid metaboli [PMID:40271063]	Gong K, Zhou S, Xiao L, Xu M, Zhou Y, Lu	Frontiers in pharmacology	2025	0
Single-cell spatial transcriptomics reveals distinct patterns of dysregulation i [PMID:39103533]	Johnston KG, Berackey BT, Tran KM, Gelbe	Molecular psychiatry	2025	0
Deferiprone in Alzheimer Disease: A Randomized Clinical Trial. [PMID:39495531]	Ayton S, Barton D, Brew B, Brodtmann A,	JAMA neurology	2025	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DISEASE-ASSOCIATED MICROGLIA in their description or question text

TREM2 haploinsufficiency dysregulates microglial synaptic surveillance, switchin

Score: 0.700 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The triggering receptor expressed on myeloid cells 2 (TREM2) functions as a criti

Disease-Associated Microglia Metabolic Reprogramming

Score: 0.631 · neurodegeneration · 2026-04-12

## Mechanistic Overview Disease-Associated Microglia Metabolic Reprogramming starts from the claim that modulating TREM2

Disease-Associated Microglia (DAM) Program Drives IBA1 Downregulation

Score: 0.571 · neuroinflammation · 2026-04-21

## Mechanistic Overview Disease-Associated Microglia (DAM) Program Drives IBA1 Downregulation starts from the claim that

Closed-loop tFUS targeting of EC-II SST interneurons to prevent ACSL4-mediated f

Score: 0.000 · Alzheimer's disease · 2026-04-26

Somatostatin-positive interneurons in entorhinal cortex layer II serve dual roles as gamma frequency gatekeepers and mic

ACSL4-Mediated Neuroinflammatory Amplification in Disease-Associated Microglia

Score: 0.000 · Alzheimer's Disease · 2026-04-26

ACSL4 (acyl-CoA synthetase long-chain family member 4) drives neuroinflammatory amplification in disease-associated micr