concept

TCA CYCLE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TCA CYCLE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

1Outgoing

14Incoming

0Experiments

0Debates

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💡 Concept Info

Name	TCA CYCLE
Key Genes/Proteins	AMPK
Related Diseases	CANCER

Pathway Diagram

graph TD
    TCA_CYCLE["TCA CYCLE"]
    TCA_CYCLE -->|"product_of"| Fumarate["Fumarate"]
    ACO2["ACO2"] -->|"involved_in"| TCA_CYCLE
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| TCA_CYCLE
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| TCA_CYCLE
    GLYCOLYSIS["GLYCOLYSIS"] -->|"activates"| TCA_CYCLE
    KEAP1["KEAP1"] -->|"activates"| TCA_CYCLE
    NRF2["NRF2"] -->|"activates"| TCA_CYCLE
    MITOPHAGY["MITOPHAGY"] -->|"regulates"| TCA_CYCLE
    PARKIN["PARKIN"] -->|"regulates"| TCA_CYCLE

Outgoing (1)

Target	Relation	Type	Str
Fumarate	product_of	compound	0.95

Incoming (14)

Source	Relation	Type	Str
ACO2	involved_in	gene	0.82
PENTOSE PHOSPHATE PATHWAY	activates	process	0.35
CANCER	activates	disease	0.35
AMPK	activates	gene	0.35
OXIDATIVE PHOSPHORYLATION	implicated_in	process	0.35
FATTY ACID OXIDATION	implicated_in	process	0.35
GLYCOLYSIS	implicated_in	process	0.35
NRF2 SIGNALING	activates	process	0.35
PENTOSE PHOSPHATE PATHWAY	regulates	process	0.35
ELECTRON TRANSPORT CHAIN	regulates	process	0.35
GLYCOLYSIS	regulates	process	0.35
OXIDATIVE PHOSPHORYLATION	interacts_with	process	0.35
ELECTRON TRANSPORT CHAIN	interacts_with	process	0.35
OXIDATIVE STRESS	interacts_with	process	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TCA CYCLE in their description or question text

No additional research found