| Gene Symbol | ACO2PROTEIN |
| Protein Family | Iron-sulfur isomerase (Aconitase) family |
| Protein Type | Enzyme |
| Function | is an iron-sulfur cluster-containing enzyme that catalyzes the reversible isomerization of citrate to isocitrate in the citric acid (TCA) cycle[@lill1999]. |
| Molecular Weight | ~82 kDa |
| Amino Acids | 780 aa |
| UniProt ID | Q99798 |
| GeneCards | ACO2PROTEIN |
| Human Protein Atlas | ACO2PROTEIN |
| Cluster composition | Four iron atoms coordinated by four inorganic sulfides |
| Cysteine ligands | Cys358, Cys360, Cys365, and Cys391 coordinate the cluster |
| Catalytic role | The cluster acts as a Lewis acid, facilitating citrate isomerization |
| Sensitivity | The cluster is highly sensitive to oxidative stress and nitric oxide |
| N-terminal domain | Contains the active site with the 4Fe-4S cluster |
| C-terminal domain | Forms a beta-barrel structure supporting the active site |
| Associated Diseases | neurodegeneration |
| Interactions | ATP, ATP5A1, CYCS, GLUD1, HSPA9, IMMUNE INFILTRATION |
| KG Connections | 82 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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