gene 2,748 words KG: SIGLEC9
Contents

SIGLEC9 — Sialic Acid Binding Ig-Like Lectin 9

🧬 Gene Info
Gene SymbolSIGLEC9
Full NameSialic Acid Binding Ig-Like Lectin 9
Chromosome19q13.4
Functionis a member of the CD33-related Siglec family of inhibitory lectins.
Primary ExpressionNeutrophils, monocytes, NK cells, B cells
Molecular Weight55 kDa
Amino Acids482 aa
Exons11
UniProt IDQ9Y736
NCBI Gene ID27180
GeneCardsSIGLEC9
Human Protein AtlasSIGLEC9
Associated DiseasesALS, Alzheimer's disease, Parkinson's disease, Tumor
InteractionsC1R, C1S, CLN5, CR1, PARP1, SIRPA
KG Connections44 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.75
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (7)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (12)

Neurodegeneration
disease · KG edge: implicated_in
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: associated_with
Tumor Necrosis Factor (TNF)
entity · KG edge: associated_with
GRN Carrier Resilience: Why Some Mutation Carriers Rema
general · KG edge: associated_with
CD4 Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

TREM2 associated_with SIGLEC9
CTSH associated_with SIGLEC9
TMEM106B associated_with SIGLEC9
SIGLEC9 associated_with SIRPA
SIGLEC9 associated_with GRN
CD4 therapeutic_target SIGLEC9
SIGLEC9 therapeutic_target GBM
SIGLEC9 associated_with TMEM106B
SIGLEC9 associated_with CTSH
C1R interacts_with SIGLEC9

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